Dose loading with delayed-release mesalazine: a study of tissue drug concentrations and standard pharmacokinetic parameters

机译：延迟释放美沙拉嗪的剂量负荷：组织药物浓度和标准药代动力学参数的研究

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摘要

AimsTissue concentrations of 5-aminosalicylic acid (5ASA) and its metabolites may influence the clinical course of inflammatory bowel disease. Since the factors that determine tissue drug concentrations are unknown we have studied the relationships between the oral dose of delayed-release mesalazine, rectal tissue drug concentrations and standard pharmacokinetic parameters.

机译：目的组织中5-氨基水杨酸（5ASA）及其代谢产物的浓度可能会影响炎症性肠病的临床进程。由于决定组织药物浓度的因素未知，因此我们研究了口服美沙拉嗪的口服剂量，直肠组织药物浓度与标准药代动力学参数之间的关系。

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期刊名称 British Journal of Clinical Pharmacology
作者
F N Hussain; R A Ajjan; S A Riley;
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作者单位

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年(卷),期 2000(49),4
年度 2000
页码 323–330
总页数 8
原文格式 PDF
正文语种
中图分类药学;
关键词
5-ASA dose-loading mesalazine pharmacokinetics tissue concentration;

机译：5-ASA;剂量负荷;美沙拉嗪;药代动力学;组织浓度;

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7. Dose loading with delayed-release mesalazine: a study of tissue drug concentrations and standard pharmacokinetic parameters [O] . Hussain, F N, Ajjan, R A, Riley, S A 2001

机译：延迟释放美沙拉嗪的剂量负荷：组织药物浓度和标准药代动力学参数的研究

Dose loading with delayed-release mesalazine: a study of tissue drug concentrations and standard pharmacokinetic parameters

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