Self-Regulating Physiologically Based Pharmacokinetic Model and Creation of Drug Concentration Profiles in Plasma and Tissues

摘要

A physiologically based pharmacokinetic model is build to determine the dynamics of drug (compound) concentration in the human body. The model consists of two major subsystems. The first subsystem simulates the diffusion of the drug(s) and respiratory gases between plasma and the tissues. Second subsystem controls the processes of the drug and gas delivery to the tissues. The system of control is based on the principles of optimal control theory and the mechanisms of self-regulation. The model allows simulation of a combined influence of multiple clearance factors. The drug is administered intravenously into the human body and goes through phases of Absorption, Distribution, Metabolism, and Excretion (ADME). The results of numerical calculations of drug concentration profiles under renal and hepatic clearance are reported The model can be tailored to suit the experimental needs in the fields of pharmacological and medical research.