Assessment of the efficacy of repeated instillations of mitomycin Cmixed with a thermosensitive hydrogel in an orthotopic rat bladder cancermodel

摘要

Background:We investigated a thermoreversible hydrogel that is highly viscous at body temperature, while fluid-like at a low temperature, thus aiming for a slow and prolonged intravesical drug release. Our study purposed to assess antitumor efficacy of mitomycin C (MMC) mixed with hydrogel in an orthotopic rat bladder cancer model.