PDTM-20. NONINVASIVE ASSESSMENT OF TREATMENT RESPONSE FOR DIFFUSE INTRINSIC PONTINE GLIOMA USING HYPERPOLARIZED 13C METABOLIC IMAGING

摘要

INTRODUCTIONIt remains often challenging on conventional MR imaging to distinguish between true versus pseudo-progression in children with diffuse intrinsic pontine glioma (DIPG). Hyperpolarized ¹³C MR metabolic imaging is a promising new technology that provides a non-invasive imaging approach to monitor changes in functional properties of tumors. We have shown previously that ¹³C-pyruvate can be used to monitor the rate and magnitude of conversion to ¹³C-lactate, which is elevated in tumors due to increased activity of the enzyme lactate dehydrogenase (LDH). We hypothesize that levels of hyperpolarized lactate, detected by monitoring hyperpolarized pyruvate metabolism using ¹³C MR metabolic imaging, will be modulated in response to therapy and might be a suitable noninvasive biomarker of therapy response.