TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA

摘要

The present invention relates to an inhibitor of MELK and/or ROR2, preferablyfor use in the treatment of diffuseintrinsic pontine glioma (DIPG), wherein said DIPG is preferably characterizedby overexpression of MELK and/or overexpression ofROR2. The inhibitor may be combined with a P-glycoprotein inhibitor, an Abcb1a inhibitor, Abcb 1b inhibitor, mannitol, or an Abcg2inhibitor.