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Discrepancies in Composition and Biological Effects of Different Formulations of Chondroitin Sulfate

机译:硫酸软骨素不同配方的组成和生物学效应差异

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摘要

Osteoarthritis is a common, progressive joint disease, and treatments generally aim for symptomatic improvement. However, SYmptomatic Slow-Acting Drugs in Osteoarthritis (SYSADOAs) not only reduce joint pain, but slow structural disease progression. One such agent is chondroitin sulfate—a complex, heterogeneous polysaccharide. It is extracted from various animal cartilages, thus has a wide range of molecular weights and different amounts and patterns of sulfation. Chondroitin sulfate has an excellent safety profile, and although various meta-analyses have concluded that it has a beneficial effect on symptoms and structure, others have concluded little or no benefit. This may be due, at least partly, to variations in the quality of the chondroitin sulfate used for a particular study. Chondroitin sulfate is available as pharmaceutical- and nutraceutical-grade products, and the latter have great variations in preparation, composition, purity and effects. Moreover, some products contain a negligible amount of chondroitin sulfate and among samples with reasonable amounts, in vitro testing showed widely varying effects. Of importance, although some showed anti-inflammatory effects, others demonstrated weak effects, and some instances were even pro-inflammatory. This could be related to contaminants, which depend on the origin, production and purification process. It is therefore vitally important that only pharmaceutical-grade chondroitin sulfate be used for treating osteoarthritis patients.
机译:骨关节炎是一种常见的进行性关节疾病,治疗通常旨在改善症状。但是,骨关节炎的症状性慢效药物(SYSADOAs)不仅可以减轻关节疼痛,而且可以减缓结构性疾病的进展。一种这样的试剂是硫酸软骨素-一种复杂的异质多糖。它是从各种动物软骨中提取的,因此分子量范围很广,硫酸化的数量和方式也不同。硫酸软骨素具有极好的安全性,尽管各种荟萃分析已得出结论,它对症状和结构具有有益作用,但其他结论几乎没有或没有益处。这可能至少部分是由于用于特定研究的硫酸软骨素的质量变化。硫酸软骨素可作为药物级和营养级产品获得,后者在制备,组成,纯度和功效方面有很大差异。此外,某些产品中硫酸软骨素的含量可忽略不计,而在合理数量的样品中,体外测试显示效果差异很大。重要的是,尽管有些药物具有抗炎作用,而另一些药物却显示出微弱的作用,有些甚至具有促炎作用。这可能与污染物有关,污染物取决于来源,生产和纯化过程。因此,至关重要的是仅将药物级硫酸软骨素用于治疗骨关节炎患者。

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