Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery

摘要

This study aimed to uncover new starting points for anti-trypansomal drug discovery through the screening of the Pathogen Box against Trypanosoma brucei brucei. Our study identified compounds >35, >39, >46, >53 and >56 whose activity and selectivity highlighted them as promising candidates with potential for further study and optimisation.