血清Apelin APN FFA及MMP与充血性心力衰竭的关系的分析

摘要

ObjectiveTo investigate the relationship between the serum Apelin,APN,FFA,MMP and congestive heart failure.Methods80 patients with congestive heart failure in our hospital from July 2012 to March 2014 were selected as observation group,80 healthy persons with health examination at the same time were the control group,then the serum Apelin,APN,FFA and MMP of two groups were detected and compared,then the serum Apelin,APN,FFA and MMP of observation group with different grades and classification were respectively analyzed and compared,then relationship between those serum items and congestive heart failure were analyzed by the logistic analysis.ResultsThe serum Apelin,APN,FFA and MMP of observation group were all higher than those of control group,those of observation group with higher grades were all higher than those of patients with lower grades, those of patients with systolic heart failure were all higher than those of patients with diastolic heart failure,and those serum indexes all had close relationship to the congestive heart failure by the Logistic analysis,allP<0.05.ConclusionThe serum Apelin,APN, FFA and MMP of patients with congestive heart failure show obvious higher state,and those serum indexes have close relationship to the congestive heart failure.%目的：探讨血清爱帕琳肽（Apelin）、脂联素（APN），游离脂肪酸（FFA）及基质金属蛋白酶（MMP）与充血性心力衰竭的关系。方法本资料中80例充血性心力衰竭患者设为观察组，同期的80名健康者为对照组，将两组的血清Apelin、APN、FFA及MMP水平进行检测及比较，然后将观察组中不同分级及分类患者的血清Apelin、APN、FFA及MMP水平进行分别统计及比较，并以Logistic分析处理上述血清项目与充血性心力衰竭的关系。结果观察组的血清Apelin、APN、FFA及MMP水平均高于对照组，且观察组中分级较高者高于分级较低者，收缩性心力衰竭患者则高于舒张性心力衰竭患者，经Logistic分析显示上述血清检测指标与充血性心力衰竭有密切的关系（P均<0.05）。结论充血性心力衰竭患者的血清Apelin、APN、FFA及MMP呈现明显升高的状态，上述血清指标均与充血性心力衰竭有密切的关系。