Objective To study the pathogenesis and risky factor in coronary heart disease(CHD) besides, to explore the value of some markers for genesis, progression, diagnosis and treatment in CHD. Methods Serum TI, Hey ( with electro chemilumines-cence),serum APN,MMP-9(with ELISA)levels were measured in 95 cases with CHD (34 SAP,36 UAP,25 AMI) and 35 normal controls. Results Serum TI,Hey,MMP-9 levels in patients with CHD were significantly higher than those in controls(P <0.01) .while the serum APN levels was lower(P <0.01). Among the CHD patients the changes of the levels on serum TI,Hey, APN,MMP-9 in AMI and UAP groups were significantly higher or lower than those in SAP group ( P < 0.05 ). Serum APN levels were negatively correlated with the serum TI,Hey,MMP-9 levels(r= -0.4612, -0.5018, -0. 6132,P <0. 01). Conclusion Detections of serum TI,APN, Hey, MMP-9 levels are related with the genesis and development of CHD. Such markers might be useful in the evaluation of diagnosis , therapy and prognosis of CHD.%目的:通过对冠心病(CHD)发生机制和危险因素的研究,探讨若干标志物对CHD的发生、发展、诊断和治疗价值.方法:应用发光免疫分析和酶联分析法对95例CHD患者进行了血清真胰岛素(TI)、同型半胱氨酸( Hcy)、脂联素(APN)、基质金属蛋白酶-9(MMP-9)的测定,其中稳定性心绞痛(SAP)34例,不稳定心绞痛(UAP) 36例,急性心肌梗死(AMI)25例.并与35名正常健康人作比较.结果:CHD患者血清TI、Hcy、MMP-9水平非常显著地高于正常人组(P＜0.01),而APN水平又非常显著地低于正常人组(P＜0.01),AMI组和UAP组又低于SAP组(P＜0.05),且血清APN水平与TI、Hcy、MMP-9水平呈显著负相关(r=-0.4612、- 0.5018、- 0.6132,P＜0.01).结论:血清TI、APN、Hcy、MMP-9水平的变化与CHD的发生、发展密切相关,是发生CHD的重要危险因素,对CHD的诊断、分型诊断、治疗和预后判断具有重要价值.
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