真胰岛素

摘要： 目的 研究T2DM患者胰岛素原(PI)、真Ins(TI)与IR的相关性,分析其对IR的影响.方法 选取2018年12月至2019年2月于徐州医科大学附属医院内分泌科住院治疗的107例T2DM住院患者,根据BMI分为体重正常组(NW,n=36)、超重组(OW,n=39)及肥胖组(OB,n=32).检测FPG、血脂各项、免疫反应性Ins(IRI)、PI、TI等.结果 与NW、OW组比较,OB组PI、TI、胰岛素抵抗指数(HOMA?IR)升高(P<0.05);各组HOMA?IR与PI(r=0.576、0.486、0.538)、TI(r=0.905、0.867、0.908)呈正相关(P<0.05).多元逐步回归分析显示,TI、PI、IRI、FPG、HDL?C是HOMA?IR的影响因素(P<0.05);偏相关分析结果显示,HOMA?IR与TI、PI呈正相关(r=0.930、0.612,P<0.01).结论 T2DM患者PI、TI均参与IR,可能是IR的影响因素.

摘要： Objective:To investigate the relationship between different glucose metabolism and serum level of 25-hydroxyvitamin D [25 (OH) D].Methods:By cross-sectional study,subjects were selected from physical examination in Nanshan hospital of Shenzhen from 2008-2014,following 75 g oral glucose tolerance test (OGTT),and divided into six groups:normal glucose tolerance (NGT),impaired fasting glucose (IFG),1 h hyperglycemia (1 h HPG),impaired glucose tolerance (IGT),IFG combined with IGT,and type 2 diabetes mellitus (T2DM)groups,50 cases in each group.Fasting blood-glucose (FPG) and post glucose load 0.5 h,1 h,2 h,3 h plasma glucose,and true insulin levels were measured.△I30/△G30,HOMA-IR,HBCI and HBCI/IR were calculated accordingly to evaluate islet function.The relationship between 25 (OH) D and glucose metabo lism was analyzed.Results:The differences of serum 25 (OH) D among the six groups were significant (P＜0.05).The NGT group exerted the highest level of 25(OH) D,while the T2DM group were found to have the lowest level of 25(OH)D.Adjusted for age,sex and body mass index,the level of 25(OH)Dwas negatively correlated to FPG,glycosylated hemoglobin and blood glucose level after OGTT (r=-0.221,-0.223,-0.224,-0.231 and-0.191,All P＜0.05),and was positively correlated to HBCI/IR(r=0.205,P＜0.01).Multivariate logistic regression analysis showed that 25 (OH)D was independent protective factor for the occurrence of abnormal glucose (P＜0.05).Conclusion:The level of 25(OH)D was negatively correlated to the blood glucose level,and 25(OH)D was independent protective factor for the occurrence of abnormal glucose.%目的:探讨人群不同糖代谢状态与血清25羟基维生素D[25(OH)D]水平的相关关系.方法:采用横断面调查研究,对2008-2014年于深圳市南山区人民医院体检的300例成年人进行口服葡萄糖耐量试验(OGTT),将其分为6组:正常糖耐量(NGT)组、空腹血糖受损(IFG)组、1h高血糖(1 h HPG)组、糖耐量异常(IGT)组、IFG合并IGT组及2型糖尿病(T2DM)组,每组50例.检测一般生化指标、空腹血糖(FPG)及糖负荷后0.5h、1h、2h、3h血糖、真胰岛素(FTI),计算糖负荷后0.5h胰岛素增量与葡萄糖增量的比值(△I30/△G30)、稳态模型胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HBCI)、校正胰岛素抵抗后的胰岛β细胞功能(HBCI/IR),分析血清25(OH)D水平与糖代谢的关系.结果:6组血清25(OH)D水平比较差异具有统计学意义(F=2.43,P=0.035);其中NGT组血清25(OH)D水平最高,T2DM组最低.校正年龄、性别、体重指数(Ibm)等因素后,25(OH)D与FPG、糖负荷后各时间点(1h、2h、3 h)血糖、糖化血红蛋白(HbA1c)呈负相关关系(r=-0.221、-0.223、-0.224、-0.231、-0.191,均P＜0.05),与HBCI/IR呈正相关关系(r=0.205,P＜0.01).多因素Logistic回归分析结果显示25(OH)D是糖代谢异常的保护因素(P＜0.05).结论:血清25(OH)D水平与血糖水平呈负相关关系,是糖代谢异常的保护因素.

摘要： 目的：探讨2型糖尿病(T2DM)患者心功能不全的临床表现特点及相关激素的改变,寻找针对糖尿病心衰干预靶点。方法 T2DM患者90例、健康对照组35例,将患者按病程和症状分为：新诊断及病程2年未发临床显性心衰症状和体征的T2DM患者32例、病程>2年且已发临床显性心衰症状和体征的T2DM患者28例、健康对照组35例。测空腹血糖( FPG)、胰岛素( FINS)、真胰岛素( TI)、胰岛素原( PI),注射胰岛素治疗患者测空腹C-肽,测定脑钠素( BNP)及采用心脏彩色多普勒测左室射血分数( LVEF)、二尖瓣口舒张早期流速峰值E峰/舒张晚期流速峰值A峰比值( E/A)、舒张早期波e峰/舒张晚期波a峰( e/a)、峰值肺静脉血流收缩期S波/峰值肺静脉舒张早、中期D波(S/D)以判定心脏功能。结果①随着T2DM的进展,BNP明显增高；临床显性心衰组TI及PI与其余各组比较有明显的降低,组间差异有统计学意义(P<0．05)；心脏彩超T2DM组较健康对照组E/A 、e/a 、S/D、LVEF有明显下降,差异有统计学意义(P<0．05)。结论随着T2DM的进展,真胰岛素、胰岛素原分泌水平减少与心肌舒张顺应性减低和收缩力下降成正相关,同时与心衰相关的激素：BNP分泌明显增加,提示胰岛素所介导的葡萄糖心脏低耗氧供能下降,使得心脏的泵功能发生因供能相关的代谢障碍,会影响和加重心衰。%Objective To investigate the clinical characteristics and related hormone changes of cardiac insufficiency in patients with type 2 diabetes mellitus(T2DM),and to seek intervention targets for the treatment of heart failure in patients with di-abetes. Methods 90 cases of T2DM patients and 35 cases in healthy control group were included. According to courses of dis-ease and symptoms,the patients were divided as follows:30 cases of T2DM patients with recent diagnosis or disease courses shorter than 2 years,32 cases of T2DM patients with disease courses longer than 2 years but without clinically overt heart failure symptoms or signs,28 cases of T2DM patients with disease courses longer than 2 years who already had clinically overt heart failure symptoms or signs and healthy control group(n=35). Fasting plasma glucose(FPG),fasting insulin(FINS),true insulin(TI) and proinsulin ( PI) were determined and as for patients receiving insulin injection treatment,fasting C-peptide was determined. Cardiac function was assessed by determination of brain natriuretic peptide( BNP) ,left ventricular ejection fraction( LVEF) ,ratio of mitral early di-astolic velocity peak E value and late diastolic velocity peak A value( E/A) ,ratio of mitral early diastolic wave peak e and late di-astolic wave peak a( e/a) and ratio of systolic S wave of peak pulmonary venous flow and early as well as mid diastolic D wave of peak pulmonary venous flow(S/D),determined by cardiac color Doppler. Results With the development of T2DM,BNP in-creased significantly. Compared with other groups,TI and PI of overt heart failure group decreased significantly,with statistically significant differences(P<0. 05). Echocardiography showed that compared with healthy control group,E/A,e/a,S/D and LVEF of T2DM group decreased obviously,with statistically significant differences(P<0. 05). Conclusion With the development of T2DM,decrease of true insulin and proinsulin secretion level and decrease of myocardial diastolic compliance and contractility fall into a positive correlation,and secretion of BNP,a kind of heart failure related hormone increases significantly,which indicates that insulin-mediated low oxygen and glucose consumption as well as low energy supply make metabolic disorders related to energy sup-ply occur to heart,affecting and worsening heart failure.

摘要： 目的 观察应激状态时,危重症患儿血糖水平变化与疾病危重程度、免疫反应性胰岛素(IRI)水平、血清真胰岛素(TI)水平变化的关系.方法 在PICU病房及呼吸科普通病房选取58例患儿入组,分别为PICU组(42例)及普通组(16例).PICU组患儿根据血糖检测结果分为高血糖组(20例)及非高血糖组(22例),并进行小儿危重评分.所有入选患儿检测血清IRI、TI、C肽及血糖.结果 高血糖组患儿入院时危重评分[(74.80±8.07)分]明显低于非高血糖组[(84.36±9.46)分],差异有统计学意义(t=1.964,P＜0.05).且高血糖组病死率(45.0％,9/20例)明显高于非高血糖组(13.6％,3/22例),差异有统计学意义(x2=5.05,P＜0.05).入院时高血糖组患儿血清IRI、TI、C肽均显著高于非高血糖组及普通组,差异有统计学意义(F=136.90、61.25、45.89,P均＜0.05).入院时高血糖组患儿TI/IRI显著低于非高血糖组及普通组,差异有统计学意义(F =27.64,P＜0.05).高血糖组患儿入院48 h TI、C肽及TI/IRI值较入院时显著降低,差异有统计学意义(=2.241、2.087、2.014,P均＜0.05).结论 危重症患儿存在应激性高血糖及血清胰岛素组分的变化,血清TI绝对水平和比例下降.%Objective To study the relationships between the level of blood glucose in critical ill children with the degree of critical illness and the variation of immunoreactive insulin (IRI) and true insulin (TI).Methods Fiftyeight children form the Neonatal Intensive Care Unit (PICU) and Department of Respiration were enrolled in this study.The children were divided into PICU group (42 cases) and control group (16 cases).The PICU group were scored pediatric critical score in 24 hours after admission.The 42 critical ill children were divided into stress hyperglycemia group (20 cases) and non-stress hyperglycemia group (22 cases) according to their blood glucose levels.The IRI,TI,C-Peptide and blood glucose were measured.Results The pediatric critical illness score of stress hyperglycemia group [(74.80 ± 8.07) scores] was significantly lower than that of non-stress hyperglycemia group [(84.36 ±9.46) scores] (t =1.964,P ＜ 0.05).The death rate of stress hyperglycemia group (45.0％,9/20 cases) was significantly higher than that of non-stress hyperglycemia group (13.6％,3/22 cases) (x2 =5.05,P ＜ 0.05).The IRI,TI and C-Peptide of stress hyperglycemia group were significantly higher than those of non-stress hyperglycemia group and control group(F =136.90,61.25,45.89,all P ＜ 0.05).The TI/IRI of stress hyperglycemia group was significantly lower than that of non-stress hyperglycemia group and control group (F =27.64,P ＜ 0.05).The TI,IRI and C-Peptide of stress hyperglycemia group were higher than after admission (t =2.241,2.087,2.014,all P ＜ 0.05).Conclusions The children with critical illness have stress hyperglycemia and the component of insulin is changed,and the absolute level as well as the rate of TI and TI/IRI are descended.

摘要： 目的观察应激状态时，危重症患儿血糖水平变化与疾病危重程度、免疫反应性胰岛素（IRI）水平、血清真胰岛素（TI）水平变化的关系。方法在PICU病房及呼吸科普通病房选取58例患儿入组，分别为PICU组（42例）及普通组（16例）。PICU组患儿根据血糖检测结果分为高血糖组（20例）及非高血糖组（22例），并进行小儿危重评分。所有人选患儿检测血清IRI、TI、C肽及血糖。结果高血糖组患儿入院时危重评分[（74．80±8．07）分]明显低于非高血糖组[（84．36±9．46）分]，差异有统计学意义（t=1．964，P〈0．05）。且高血糖组病死率（45．0％，9／20例）明显高于非高血糖组（13．6％，3／22例），差异有统计学意义（χ2=5．05，P〈0．05）。入院时高血糖组患儿血清IRI、TI、C肽均显著高于非高血糖组及普通组，差异有统计学意义（F=136．90、61．25、45．89，P均〈0．05）。入院时高血糖组患儿TI／IRI显著低于非高血糖组及普通组，差异有统计学意义（F=27．64，P〈0．05）。高血糖组患儿入院48hTI、c肽及TI／IRI值较入院时显著降低，差异有统计学意义（t=2．241、2．087、2．014，P均〈0．05）。结论危重症患儿存在应激性高血糖及血清胰岛素组分的变化，血清TI绝对水平和比例下降。

摘要： 目的：探讨2型糖尿病（DM）患者空腹血糖（FPG）的水平变化是否与真胰岛素（TI）有关；2型DM患者TI受血糖影响与TI真实水平的±据。方法正常对比组100例，2型DM组200例。将这200患者中空腹血糖的浓度范围6.0~10 mmol/L间137例划为A组，浓度>10 mmol/L的63例划为B组。300例相关人员均与早晨空腹采集3mL静脉血送检测，FPG用全自动的生化分析仪测，真胰岛素用化学发光免疫的分析法（CLIA）检测。精密的操作以保证结果的准确性。结果2型DM患者真胰岛素浓度（34.56±20.51）p mol/L；正常对比组真胰岛素浓度（33.00±19.05）p mol/L。2型DM患者中A组的TI浓度（36.00±24.57）p mol/L；B组的TI浓度（39.51±23.46）p mol/L。各组间并没有统计学的意义（P>0.05）。对2型DM组FPG和TI统计，其相关的系数r=0.0056，回归方程是Y=35.998+0.038X，FPG与TI的浓度是正相关。结论2型DM患者TI浓度会随FPG的浓度上升而上升，两者呈正直线相关。证实2型糖血糖可以调节2型DM患者的空腹胰岛素，所以对2型糖尿病患者而言维持着血糖的稳定是必要的。

摘要： 目的 分析2型糖尿病患者空腹血清真胰岛素(TI)水平的变化趋势及临床意义.方法 采用微粒子化学发光免疫分析法测定本院收治的68例糖尿病患者(观察组)空腹血清TI水平,与同期入院体检的68例健康志愿者(对照组)比较；并测定各组患者空腹血糖(FBG)、尿酸(UA)、C肽水平及胰岛素抵抗指数(HOMA-IR),分析TI水平的改变趋势及临床意义.结果 与对照组相比,观察组患者TI水平显著升高(P＜0.05)；且观察组患者血清FBG、UA、C肽及HOMA-IR水平均显著升高(P＜0.05)；经Pearson直线相关性分析,TI与血清FBG、UA、C肽及HOMA-IR水平均有直线正相关性(P＜0.05).结论 糖尿病患者TI水平异常增高,TI升高水平可反映血糖、尿酸代谢障碍,肾功能损伤程度及胰岛素抵抗水平,对糖尿病的临床诊断、治疗及预后评估有一定的指导意义.

摘要： Objective To investigate the change and clinical significance of plasma endothelin-1(ET-1) and serum intact insulin (TI),adiponectin (APN),homocysteine(Hcy) levels before and after treatment in patients with coronary heart diseases (CHD).Methods The plasma ET-1 and serum TI (with RIA),APN (with Elisa),Hcy (with electrochemiluminescence) levels were measured in 65 patients with CHD,and the results were compared with those of 35 healthycontrols.Results Before treatment,the plasma ET-1 and serum TI,Hcy levels in patients with CHD were significantly higher than those in controls(P ＜ 0.01),while the serum APN level was significantly lower than that in controls (P ＜ 0.01).After combined treatment of traditional Chinese medicine and western medicine for 3 months,there was no significant difference between patients with CHD and healthy people(P ＞ 0.05).Conclusions The plasma ET-1 and serum TI,APN,Hcy levels take part in the development of CHD.%目的 探讨冠心病(CHD)患者治疗前后血浆内皮素-1(ET-1)和血清真胰岛素、脂联素、同型半胱氨酸水平的变化及临床意义.方法 应用放射免疫分析法、酶联法和化学发光法对65例CHD患者(研究组)进行了血浆ET-1和血清真胰岛素、脂联素和同型半胱氨酸水平检测,并与35例正常健康人(对照组)作比较.结果 CHD患者在治疗前血浆ET-1和血清真胰岛素、同型半胱氨酸水平均显著高于对照组(P＜0.01),而脂联素水平显著低于对照组(P＜0.01),经中西医结合治疗3个月后则与对照组比较差异无统计学意义(P＞0.05).结论 血浆ET-1和血清真胰岛素、脂联素和同型半胱氨酸水平的变化参与了CHD的发生与发展.

摘要： 目的 研究2型糖尿病患者中血清尿酸(SUA)与真胰岛素(TI)、胰岛素原(PI)的关系.方法 79例受试者以SUA均值为界值分为两组,SUA高于均数组(B组)及低于均数组(A组)均行空腹糖耐量试验,空腹采血测定SUA、TI、PI及血脂(TC、TG、LDL-C、HDL-C、Apo-A1、Apo-B)、血糖、糖化血红蛋白(HbA1c),糖负荷后2 h采血测定血糖(2hPG)、TI(2hTI)、PI(2hPI),计算胰岛素敏感指数(ISI)和胰岛素抵抗指数(HOMA-IR),进行比较和分析.结果 B组男性较多,较肥胖,血压较高,TI、PI、2hTI、2hPI、TG、LDL-C、Apo-B高于A组,HDL-C、Apo-A1、低于A组,ISI降低,HOMA-IR升高,在B组,尿酸与TI、PI、HOMA-IR呈正相关,与ISI呈负相关,经多元logistic回归分析,TI、PI是尿酸升高的危险因素.结论 2型糖尿病血尿酸较高患者,更多伴有肥胖、血脂异常、血压升高,更具有高胰岛素血症、高胰岛素原血症及胰岛素抵抗倾向.

摘要： Objective To study the pathogenesis and risky factor in coronary heart disease(CHD) besides, to explore the value of some markers for genesis, progression, diagnosis and treatment in CHD. Methods Serum TI, Hey ( with electro chemilumines-cence),serum APN,MMP-9(with ELISA)levels were measured in 95 cases with CHD (34 SAP,36 UAP,25 AMI) and 35 normal controls. Results Serum TI,Hey,MMP-9 levels in patients with CHD were significantly higher than those in controls(P <0.01) .while the serum APN levels was lower(P <0.01). Among the CHD patients the changes of the levels on serum TI,Hey, APN,MMP-9 in AMI and UAP groups were significantly higher or lower than those in SAP group ( P < 0.05 ). Serum APN levels were negatively correlated with the serum TI,Hey,MMP-9 levels(r= -0.4612, -0.5018, -0. 6132,P <0. 01). Conclusion Detections of serum TI,APN, Hey, MMP-9 levels are related with the genesis and development of CHD. Such markers might be useful in the evaluation of diagnosis , therapy and prognosis of CHD.%目的:通过对冠心病(CHD)发生机制和危险因素的研究,探讨若干标志物对CHD的发生、发展、诊断和治疗价值.方法:应用发光免疫分析和酶联分析法对95例CHD患者进行了血清真胰岛素(TI)、同型半胱氨酸( Hcy)、脂联素(APN)、基质金属蛋白酶-9(MMP-9)的测定,其中稳定性心绞痛(SAP)34例,不稳定心绞痛(UAP) 36例,急性心肌梗死(AMI)25例.并与35名正常健康人作比较.结果:CHD患者血清TI、Hcy、MMP-9水平非常显著地高于正常人组(P＜0.01),而APN水平又非常显著地低于正常人组(P＜0.01),AMI组和UAP组又低于SAP组(P＜0.05),且血清APN水平与TI、Hcy、MMP-9水平呈显著负相关(r=-0.4612、- 0.5018、- 0.6132,P＜0.01).结论:血清TI、APN、Hcy、MMP-9水平的变化与CHD的发生、发展密切相关,是发生CHD的重要危险因素,对CHD的诊断、分型诊断、治疗和预后判断具有重要价值.

摘要： 目的：研究妊娠糖尿病(GDM)和正常哺乳期妇女初乳、42天和90天成熟乳中胃生长素、脂联素、瘦素、真胰岛素的水平、影响因素、相互联系及其对婴儿体格发育的影响.方法：选取2010年1～8月在北京协和医院产科及北京妇产医院产科确诊为GDM、单胎足月分娩的产妇及其新生儿为GDM组,无妊娠合并症的健康产妇及其单胎足月新生儿为正常对照组.采集产妇及新生儿的基本情况,采用酶联免疫分析法(ELISA)测定产妇的初乳、42天和90天成熟乳及新生儿脐血中胃生长素、脂联素、瘦素、真胰岛素水平,监测产后90天内母婴健康状况、婴儿喂养方式和生长情况.结果:共入组101对母婴，GDM组52对，正常组49对。研究显示，(1)脐血中胃生长素水平高于母乳。(2)脐血中脂联素水平远高于母乳。(3)GDM组脐血中瘦素水平高于正常组。(4)母乳中真胰岛素水平高于脐血中真胰岛素水平。GDM组脐血中真胰岛素水平高于正常组中真胰岛素水平。GDM组初乳中真胰岛素水平高于正常组中真胰岛素水平。90天成熟乳中的真胰岛素水平高于正常组中的真胰岛素水平。OGTT值和有无糖尿病家族史是GDM母乳中胃生长素水平的影响因素;影响脂联素水平的因素有:母亲年龄、孕期空腹血糖值和喂养方式;影响GDM婴儿脐血和GDM母亲母乳中瘦素水平的因素有:母亲BMI,OGTT值、50g口服葡萄糖耐量值和喂养方式;影响GDM母乳中真胰岛素水平的因素有:母亲日MI、孕期糖化血红蛋白百分比、分娩方式和喂养方式。两组婴儿脐血、母亲初乳成熟乳中瘦素、瘦素/脂联素比值脂连素、真胰岛素水平等均显示出与出生、生后42天及90天时体重、身长、头围等存在一定的关系。结论:由于代谢异常，GDM组母亲母乳中和新生儿脐血中的激素水平与正常组不同。母乳中多种激素相关联相互影响、互相调节，共同作用于婴儿的生长发育。GDM的因素使母乳中激素水平的改变，可能对下一代生长起到控制体重、防止肥胖的作用。

摘要： 通过更简便的方法评价胰岛素分泌能力。具备：至少输入空腹时血糖值和HbA1c值的输入部；根据输入的空腹时血糖值和HbA1c值计算推定HbA1c值的推定HbA1c计算部；基于通过所述输入部输入的HbA1c值和通过所述推定HbA1c计算部计算出的推定HbA1c值来计算胰岛素分泌能力评价值的胰岛素分泌能力评价值计算部。

摘要： 本发明公开了一种短直链淀粉‑胰岛素或短直链淀粉‑胰岛素‑原花青素纳米复合物的制备方法，所述方法将短直链淀粉、胰岛素两者或短直链淀粉、胰岛素、原花青素三者混合后回生制得短直链淀粉‑胰岛素或短直链淀粉‑胰岛素‑原花青素纳米复合物。本发明短直链淀粉‑胰岛素或短直链淀粉‑胰岛素‑原花青素纳米复合物粒径较小，可以紧密的粘附在小肠的膜粘附层，延长在胃肠带停留时间，同时可以克服消化道系统中存在的粘液层屏障、酶屏障及上皮屏障，提高口服胰岛素的生物利用率。

摘要： 本发明涉及用作糖尿病治疗剂等并具有优异的胰岛素致敏剂和胰岛素促分泌素的溶出性能的固体制剂，其包含胰岛素致敏剂、胰岛素促分泌素和聚氧乙烯脱水山梨糖醇脂肪酸酯。

摘要： 本发明公开了一种胰岛素泵用胰岛素输注控制方法、系统以及胰岛素泵，所述方法包括：a.利用主控制器读取输注数据，包括输注时刻及输注量数据；b.向电机驱动控制器发送输注信息；c.根据输注信息，设置电机运行超时时间以及编码盘预制值；d.启动电机输注胰岛素；e.判断电机运行是否超时，如果判断超时，则向主控制器发送输注失败信息，然后重复步骤b；如果判断不超时，则进行步骤f；f.判断编码盘计数是否到预制值，如果否，则重复步骤e；如果是，则进行步骤g；以及g.停止输注胰岛素，并向主控制器发送输注成功信息，重复步骤a，进入下一次输注操作。

摘要： 通过更简便的方法评价胰岛素分泌能力。具备：至少输入空腹时血糖值和HbA1c值的输入部；根据输入的空腹时血糖值和HbA1c值计算推定HbA1c值的推定HbA1c计算部；基于通过所述输入部输入的HbA1c值和通过所述推定HbA1c计算部计算出的推定HbA1c值来计算胰岛素分泌能力评价值的胰岛素分泌能力评价值计算部。

摘要： 用于治疗糖尿病的胰岛素、胰岛素类似物或胰岛素的衍生物。所述用途包括胰岛素类似物的新的施用途径。

摘要： 本发明公开了一种短直链淀粉‑胰岛素或短直链淀粉‑胰岛素‑原花青素纳米复合物的制备方法，所述方法将短直链淀粉、胰岛素两者或短直链淀粉、胰岛素、原花青素三者混合后回生制得短直链淀粉‑胰岛素或短直链淀粉‑胰岛素‑原花青素纳米复合物。本发明短直链淀粉‑胰岛素或短直链淀粉‑胰岛素‑原花青素纳米复合物粒径较小，可以紧密的粘附在小肠的膜粘附层，延长在胃肠带停留时间，同时可以克服消化道系统中存在的粘液层屏障、酶屏障及上皮屏障，提高口服胰岛素的生物利用率。

摘要： 本发明涉及组合产品，例如分别为组合的制剂或药用组合物，所述组合产品含有肾素抑制剂或其药学上可接受的盐以及至少一种选自下列的治疗成分：(a)胰岛素分泌促进剂或其药学上可接受的盐；和(b)胰岛素敏化剂或其药学上可接受的盐。

摘要： 本发明涉及用作糖尿病治疗剂等并具有优异的胰岛素致敏剂和胰岛素促分泌素的溶出性能的固体制剂，其包含胰岛素致敏剂、胰岛素促分泌素和聚氧乙烯脱水山梨糖醇脂肪酸酯。

摘要： 本发明涉及①具有与SEQ ID NO：7所示氨基酸相同或基本相同的多肽(A链)；②具有与SEQ ID NO：8所示氨基酸相同或基本相同的多肽(B链)；③A链和B链通过二硫键联结形成的多肽或其盐(2条链)；④编码它们的DNA等。本发明多肽以及编码该多肽的DNA，可用于诊断、治疗、预防碳水化合物等能源代谢调节(糖代谢、脂肪代谢等)紊乱(如糖尿病等)等疾病。