cqvip:We investigated coexisting autoantibodies in sera of 553 patients with a neurological presentation and one or more paraneoplastic neuronal nuclear or cytoplasmic autoantibodies: antineuronal nuclear autoantibody type 1 (ANNA- 1), ANNA- 2, ANNA- 3; Purkinje cell cytoplasmic autoantibody type 1 (PCA- 1), PCA- 2; and CRMP- 5- immunoglobulin G or amphiphysin- immunog- lobulin G. Except for PCA- 1, which occurred alone, 31% of sera had more than one of these autoantibodies. In addition, 25% of sera had neuronal calcium channel (P/Q- type or N- type), potassium channel, ganglionic acetylcholine receptor, muscle acetylcholine receptor, or striational anti- bodies. The autoantibody profiles observed in patients with paraneoplastic disorder simply the targeting of multiple onconeural antigens and predict the patient s neoplasm, but not a specific neurological syndrome.
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