男性不育影响因素的病例对照研究

摘要

目的:探讨男性不育的影响因素.方法:对122对病例和对照以1∶2配对进行影响因素的面对面问卷调查,采用Epidata3.0软件建立数据库,SPSS11.5软件进行单因素和多因素条件Logistic回归分析.结果:多因素条件Logistic回归分析表明:泌尿生殖系统感染史(OR=11.248)、肝病史(OR=12.247)、高温作业(OR=1.743)、接触有害化学物质(OR=1.597)、精神压力(OR=1.382)及每月性交次数(OR=1.378)均可能是男性不育的危险因素,而文化程度(OR=0.379)可能为其保护因素.结论:男性不育可能是由多种因素长期反复作用的结果,其预防措施的重点应为整治环境污染、加强职业防护、提高文化知识和性健康教育水平、改变不良工作及生活习惯等.%Objective:To study the risk factors of male infertility.Methods :A hospital-based matched case-control study was carried out in Nanchang.Matched by age (±2 years old), 122 cases and 240 controls(1∶2) were recruited and studied.Database was established with Epidata3.0 software.Both cases and controls were face to face interviewed with a uniformed questionnaire.Conditional logistic regression model was used for univariate and multivariate analysis on SPSS 11.5 to estimate odds ratios (OR) and 95 percent confidence internals (95％CI).Results :Data from multiple conditional logistic regression analysis showed that the risk factors of infertility were history of genitourinary infection (OR=11.248) ,history of liver disease(OR = 1.2.247) , high-temperature operation (OR = 1.743) , occupational exposure to chemical substances (OR = 1.597), mental stress (OR = 1.382)and the monthly frequency of sexual intercourse (OR= 1.378).However, level of education(OR=0.379) was the protective factor of male infertility.Conclusion :Male infertility is resulted from many factors repeatedly acting on men for a long time.In order to prevent male infertility,issues as environmental pollution,occupational protection and education of sexual health need to be improved while bad working condition and risky behavior should be changed.