PI3 K／AKT／mTOR 信号通路在乳腺癌 Her -2治疗耐药中的作用研究进展

摘要

Her-2靶向治疗是Her-2过表达乳腺癌治疗的重要组成部分，但Her-2靶向治疗的耐药严重影响了乳腺癌的治疗。研究证实乳腺癌Her-2靶向治疗出现耐药的过程中有PI3K/AKT/mTOR信号通路的激活，因此对PI3K/AKT/mTOR信号通路及以PI3K/AKT/mTOR信号通路为靶点的药物研究对乳腺癌治疗具有重要意义。%Her-2 targeting therapy is an important part of the treatment for breast cancer with Her -2 overexpression.However,the therapeutic effectiveness is largely influenced by Her -2 resistance.Previous studies have confirmed that PI3K/AKT/mTOR signaling pathway is activated during the process of drug resistance to Her-2-targeting therapy.Therefore,investigating the PI3K/AKT/mTOR signaling pathway and drugs -targeted pathway are important for the treatment of breast cancer .