胰岛素生长因子与组织蛋白酶 B 在慢性阻塞性肺疾病患者血液中的表达水平及其临床意义

摘要

目的：探讨慢性阻塞性肺疾病（ chronic obstructive pulmonary disease ，COPD）患者血液中胰岛素生长因子（ IGF）与组织蛋白酶B（ CB）的变化及其临床意义。方法选取60例不同分级的COPD患者及40例健康对照者，测定血清中的IGF-I、IGF-II和CB含量，分析COPD患者血液中IGF和CB水平变化，并与健康对照组进行对比。结果 COPD组血清IGF-I、IGF-II水平明显高于对照组，CB水平明显低于对照组（ P＜0.05），不同分级COPD患者IGF-I、IGF-II及CB水平差异均有统计学意义（P＜0.05）；CB水平与IGF-I、IGF-II水平均呈负相关关系（r分别为-0.513，-0.462，P＜0.05）。结论 IGF和CB表达水平的检测对了解COPD患者病情的发生发展具有重要的临床意义。%Objective To explore the changes and clinical significance of insulin-like growth factor ( IGF) and Cathepsin B (CB) in patients with chronic obstructive pulmonary disease (COPD).Methods Sixty cases with different classification of COPD pa-tients and 40 healthy people were included in the study .The serum levels of IGF-I,IGF-II and CB were measured .Results Compared with the control group ,the level of IGF-I,IGF -II were higher and the level of CB was lower in the COPD group ( all P <0.05 ) .The levels of IGF-I,IGF-II in the COPD group were increased while the levels of CB in the COPD group were decreased with the disease classification ( all P<0.05 ) .Correlation analysis showed that the levels of CB were negatively correlated with IGF -I and IGF-II in the sera in the COPD group ( r=-0.513 ,r=-0.462 ,P<0.05 ) .Conclusion The detection of levels of IGF and CB in COPD patients has an important clinical significance in occurrence and development of COPD .