COPD患者血液中组织蛋白酶B和胰岛素样生长因子的观察结果分析

摘要

目的：分析COPD患者血液中组织蛋白酶B和胰岛素样生长因子表达。方法分析在我院接受治疗的COPD患者的临床资料( COPD组),另选取45例健康志愿者作为对照组。结果共纳入COPD组60例,对照组45例。 COPD组肿瘤坏死因子α及C-反应蛋白均显著高于对照组(P<0．05)；组织蛋白酶B显著低于对照组(P<0．05)。两组CD4+/CD8+比较无显著性差异(P>0．05)。随着COPD级数升高,ICF-1水平不断升高,而组织蛋白酶B水平逐渐下降(P<0．05)。相关性分析显示,COPD患者血ICF-1与组织蛋白酶B呈现显著负相关(P<0．001)。结论 COPD患者ICF-1表达随疾病严重程度升高而增多,而组织蛋白酶B则随疾病严重程度升高而降低。%Objective To analyze the expression of IGF-1 and cathepsin B in patients with chronic obstruc-tive pulmonary disease ( COPD) . Methods The clinical data of 60 COPD patients were retrospectively analyzed. 45 healthy volunteers were selected as the control group. Results The levels of CRP, TNF-αand IGF-1 was obviously higher in the COPD group than in the control group (P<0. 05). The level of IGF-1 got higher and cathepsin B got lower with the increase of COPD levels. Cathepsin B had a significantly negative correlation with IGF-1 ( r = -0. 419, P<0. 001). Conclusion The level of ICF-1 increases with the severity of disease, while cathepsin B de-creases with the severity of disease.