西洛他唑对老年急性冠脉综合征患者血清炎性细胞因子及血脂代谢的影响

摘要

目的 探讨西洛他唑对老年急性冠脉综合征患者血清中炎性细胞因子及血脂的影响. 方法 选择老年急性冠脉综合征患者60例,随机分为基本治疗组和西洛他唑组,同时以30例健康体检人员作为正常对照组.基本治疗组给予常规药物和阿托伐他汀治疗,西洛他唑组在基本治疗组所用药物外,增加西洛他唑.治疗6周后观察各组血清中白介素-1β、超敏C反应蛋白、基质金属蛋白酶-9及血脂的变化. 结果 2组治疗后白介素-1β、超敏C反应蛋白、基质金属蛋白酶-9水平较治疗前均有下降(P＜0.05),但西洛他唑组下降幅度大于基本治疗组(P＜0.05).2组治疗后血脂水平均较前改善,且西洛他唑组改善较基本治疗组明显(P＜0.05). 结论 西洛他唑具有降低炎性因子浓度、调节血脂代谢的作用,对于老年急性冠脉综合征患者的治疗具有积极意义.%Objective To observe the effects of cilostazol on the serum level of interleukin-1β(IL-1β),high-sensitive C reactive protein (hs-CRP),blood lipid and matrix metalloproteinase-9 (MMP-9) in the elderly patients with acute coronary syndrome (ACS).Methods Sixty elderly patients with ACS were randomly assigned to conventional therapy group and cilostazol group.Thirty healthy people were selected as the normal group.The patients in conventional therapy group were given routine treatment.The patients in cilostazol group were given cilostazol besides routine treatment.The serum levels of IL-1β,hs-CRP,blood lipid and MMP-9 were measured before and 6 weeks after therapy.Results The levels of IL-1β,hs-CRP and MMP-9 were significantly decreased in both groups (P ＜ 0.05),especially in cilostazol group (P ＜ 0.05).The level of blood lipid was also significantly improved in both group(P ＜ 0.05),and the improvement was more significant in cilostazol group (P ＜ 0.05).Conclusions The therapy of cilostazol can adjust blood lipid metabolism and decrease the level of inflammatory factors.