Clinical effect of tiotropium bromide on pulmonary function,arterial blood gas and serum inflammatory cytokine in elderly patients with COPD at stable stage

摘要

Objective: To observe the clinical effect of tiotropium bromide in elderly patients with COPD at stable stage and its effects on pulmonary function,blood and serum inflammatory cytokine. Methods: 80 elderly patients with COPD s at stable stage were randomly divided into treatment group and control group with 40 patients in each group. The control group was treated with normal treatment. The treatment group was treated with tiotropium bromide on the basis of control group. 3 months after treatment, the pulmonary function、arterial blood gas and serum inflammatory cytokine were detected and compared in the two groups. Results:There was no significant difference in lung function index and TNF- alpha level between the two groups before treatment (P>0.05). The levels of FVC, FEV1％ and PEF were increased and serum TNF-α was decreased significantly after treatment in two groups (P<0.05), and they were better than in treatment group than those in control group (all P<0.05); There was no significant difference in blood gas index between the two groups before treatment (P>0.05);In addition, there were no significant difference in the level of PCT, PaO2, PaCO2 and PaO2/FiO2 after treatment in control group, but the level of PCT and PaCO2 were higher and PaO2 and PaO2/FiO2 were lower obviously after treatment (P<0.01). The treatment group was superior to the control group (all P<0.05); Moreover, the curative effect of treatment group was better than that in control group (P<0.05). Conclusion: Tiotropium bromide can improve pulmonary function, pulmonary function、arterial blood gas and serum inflammatory cytokine in elderly stable COPD patients.