线性扫描极谱法测定消旋山莨菪碱

摘要

用线性扫描极谱法和循环伏安法研究了消旋山莨菪碱在0.3 mol·L-1磷酸氢二钠-磷酸二氢钾缓冲溶液(pH 6.70)中的电化学行为.消旋山莨菪碱于-1.095 V(vs.SCE)处产生一灵敏的吸附波,消旋山莨菪碱质量浓度在0.10～10.0 mg·L-1范围内与其一次微分线性扫描峰电流ip呈线性关系,检出限(3S/N)为0.06 mg·L-1.对5.0 mg·L-1消旋山莨菪碱溶液进行6次平行试验,相对标准偏差为0.34%,该方法用于片剂中消旋山莨菪碱含量的测定,测定值与标示值相符.%Electrochemical behavior of receanisodamine was studied by linear scanning polarography and cyclic voltammetry.In a PBS of pH 6.70, a sensitive adsorptive wave of Raceanisodamine was observed at the potential of -1.095 V (vs.SCE).Linear relationship between values of 1st derivative peak current and concentration of raceanisodamine was kept in the range of 0.10-10.0 mg · L-1 , with its detection limit (3S/N) of 0.06 mg ·L-1.Precision was tested at the concentration level of 5.0 mg · L-1, value of RSD (n=6) found was 0.34％.The method was used in the analysis of raceanisodamine tablets, giving results in consistency with the labelled value.