Second order derivative linear-sweep polarographic determination of capecitabine in pharmaceutical formulations

摘要

A sensitive electrochemical method for the determination of anticancer drug capecitabine (CPT) was established, by using the second order derivative linear-sweep polarography. A well-defined reduction peak of CPT was observed at the potential of -1.19 V in pH 5.0 Britton-Robinson (BR) buffer, which was attributed to the reduction of carbonyl group with the N-C bond cleavage on the mercury electrode. The optimal conditions for the CPT determination were optimized. Under the selected conditions the reduction peak currents were found to be linearly dependent on the CPT concentration in the range from 1.0 x 10~(-7) to 1.0 x 10~(-5) mol/L with the detection limit 8.53 x 10~(-8) mol/L (3a). This proposed method was further applied to determine the CPT contents in Xeloda tablet sample successfully.