Starch derivatives were obtained from Crosslinked High Amylose Starch (HASCL) by substitution with Carboxymethyl (CM-), Aminoethyl (AE-) or Acetate (Ac-) groups. The new polymers are able to generate ionic or neutral networks involved in the control of drug release. Surprisingly, it was found that the drug loading capacity of the new derivatives was markedlly higher compared to the unsubstituted HASCL. The HASCL derivatives ensured a close to linear release for 16-24h and they were proposed as excipients for oral solid dosage forms. Dissolution kinetics and mechanistic studies (related to swelling and diffusion aspects) allowed a better understanding of the physical and molecular phenomena controling the drug delivery from these novel matrices.
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