线性扫描极谱法测定尼美舒利

摘要

用线性扫描极谱法和循环伏安法研究尼美舒利在0.02 mol·L-1 KH2PO4-Na2HPO4缓冲溶液(pH 9.01)中的电化学行为，尼美舒利于-0.782 V( vs. SCE)处产生一灵敏的吸附波，在尼美舒利浓度为0.5~100.0 mg·L-1范围内，其一次微分线性扫描峰电流与尼美舒利浓度呈良好的线性关系，相关系数r=0.9981(n=15)，检出限为0.4 mg·L-1。对100 mg·L-1尼美舒利溶液进行6次平行试验， RSD为1.24％，回收率在97.2％~104.1％之间，方法可用于其在片剂中含量的测定。%The electrochemical behavior of Nimesulide was studied in linear scanning polarographic method. In an phosphate buffer solution of pH 9. 01, a sensitive reductive wave of Nimesulide appeared at-0. 782 V ( vs. SCE) . The linear relationship between the peak current and the Nimesulide concentration in the range of 0. 5~100. 0 mg·L-1 ( r=0. 9981 , n=15 ) were observed. The detection limit of the method was 0. 4 mg · L-1 . RSD found from the data of 6 independent determinations at the concentration level of 100. 0 mg · L-1 was 1. 24%. Recoveries obtained were in the range of 97. 2% ~104. 1%. This method was applied to the analysis of Nimesulide in tablets.