线性扫描极谱法测定盐酸乙哌立松

摘要

用线性扫描极谱法研究盐酸乙哌立松的电化学行为。在pH4．73的0．15mol·L-1乙酸-乙酸钠缓冲溶液中，盐酸乙哌立松于-1．269V（vs．SCE）处产生一灵敏的吸附波，其一次微分线性扫描峰电流与盐酸乙哌立松质量浓度在0．050-250．0mg·L-1范围内呈线性关系，检出限（3S／N）为0．040mg·L-1。对50．0mg·L-1盐酸乙哌立松溶液进行6次平行试验，相对标准偏差（n=6）为0．98％，方法可用于其片剂中盐酸乙哌立松含量的测定。%It was found that in an acetate buffer solution of pH 4. 73 and by the linear scanning polarography, a sensitive adsorption wave of eperisone hydrochloride was observed at the potential of --1. 269 V (vs. SCE). Linear relationship between values of the 1st derivative of peak current and mass concentration of eperisone hydroehloride was obtained in the range of 0. 05--250.0 mg · L-1 with detection limit (3S/N) of 0. 04 mg · L-1. Precision was tested with standard solution of eperisone hydrochloride of 50. 0 mg · L-1 for 6 determinations, value of RSD found was 0. 98%. The proposed method has been used in the determination of content of eperisone hydrochloride in its tablets.