影响原发性癫痫患者发生认知功能障碍的危险因素分析

摘要

Objective:To analyze the risk factors of cognitive dysfunction in patients with primary epilepsy.Methods:The cognitive dysfunction of one hundred cases with primary epilepsy (study group) and 50 healthy controls (control group) were evaluated by Wechsler Adult Intelligence Scale scale (WAIS-RC) cognitive function test.The related factors affecting the cognitive function were analyzed by single factor analysis and multiple linear stepwise regression analysis.Results:The scores of knowledge,comprehension,arithmetic and other 11 parameters scored in the cognitive function test of the study group were significantly lower than those in the control group (P＜0.001).Verbal IQ (VIQ) scores,performance IQ (PIQ) scores and full scale IQ (FIQ) in the study group were significantly lower than those in the control group (P＜0.001).Correlation analysis showed that FIQ and education,physical quantity,time of onset and seizure duration were significantly correlated with the injury(R=0.611).VIQ was significantly related to education and the number of anti-epileptic drugs (R=0.619).The PIQ was significantly related to time of onset,age,the number of antiepileptic drugs and education (R=0.571).Conclusion:The incidence of cognitive dysfunction in patients with primary epilepsy is significantly related to the degree of education,age,duration of disease,the number of antiepileptic drugs,and the duration of attacks.%目的:分析影响原发性癫痫患者发生认知功能障碍的危险因素.方法:采用韦氏成人智力量表(WAIS-RC)对研究组100例原发性癫痫患者与对照组50例健康体检者进行认知功能测验,同时对影响认知功能的相关因素进行单因素分析与多元线性逐步回归分析.结果:研究组患者认知功能测验中知识、领悟、算术等11个分测量指标得分均显著低于对照组(P＜0.001);研究组言语智商(VIQ)、操作智商(PIQ)及全量表智商(FIQ)得分显著低于对照组(P＜0.001);相关性分析结果显示FIQ与学历、抗癫痫药物数量、发作时间及病程显著相关(R=0.611),VIQ与学历、抗癫痫药物数量显著相关(R=0.619),PIQ与发作时间、年龄、抗癫痫药物数量及学历显著相关(R=0.571).结论:原发性癫痫患者认知功能障碍的发生与学历、年龄、病程、抗癫痫药物数量、发作持续时间等因素显著相关.