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Human papillomavirus infection in HIV-seropositive men who have sex with men in both the United States and India: Prevalence, incidence, and risk factors for infection.

机译:在美国和印度与男性发生性行为的HIV阳性男性中的人乳头瘤病毒感染:感染的发生率,发生率和危险因素。

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摘要

Human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) are at high risk of anal cancer compared with the general population. Human papillomavirus (HPV) infection, particularly HPV 16, causes anal cancer. The prevalence of anal HPV infection among HIV-infected men in the US is >90% but little is known about the risk factors for prevalence, and incidence of or the risk factors for type-specific anal HPV infection. There is also limited knowledge about anal HPV infection among HIV-infected MSM in India, although the background incidence of HPV-related cancers in both men and women is high in India. Indian HIV-infected MSM may be at especially high risk for anal HPV infection and HPV-associated disease.;My aim was to determine the prevalence and incidence of and risk factors for anal HPV infection among two populations of HIV-infected MSM, one from San Francisco and the second from India. The San Francisco population was two-year longitudinal study and allowed for both prevalence and incidence analysis; the India study was cross-sectional in design and allowed only for a prevalence analysis.;The prevalence of anal HPV infection among HIV-infected MSM in San Francisco was 92%, 80% had oncogenic types and 42% had HPV 16. A higher number of total life-time partners was associated with increased prevalence of HPV 16. The incidence of any anal HPV infection was 21.3 per 100 person-years (PY) and 3.5/100 for HPV 16. A higher number of recent partners with whom the participant was the receptive partner was associated with a higher incidence of any anal HPV infection. New receptive partners, more frequent receptive sex, and new oral-anal contact partners was also associated with a higher incidence of any anal HPV infection. The prevalence of anal HPV infection among HIV-infected Indian MSM was 71%, and ever having receptive anal intercourse and higher number of receptive partners increased prevalence. "Almost always" condom use with receptive anal intercourse decreased prevalence of anal HPV infection among HIV-infected Indian MSM.;In conclusions, HIV-infected MSM in both San Francisco and India have high prevalences of anal HPV infection and the incidence of anal HPV among these men in San Francisco is also high. The most important risk factors for infection are total number of male partners and receptive anal intercourse. Condoms may protect against anal HPV infection, but further research is needed to confirm results. HIV-infected MSM should be counseled on safe sex practices with all partners and encouraged to receive the recently recommended HPV vaccine.
机译:与普通人群相比,与男性发生性关系(MSM)的感染了人类免疫缺陷病毒(HIV)的男性患肛门癌的风险较高。人乳头瘤病毒(HPV)感染,尤其是HPV 16,会引起肛门癌。在美国,被HIV感染的男性中,肛门HPV感染的患病率> 90%,但对流行的危险因素,特定类型的肛门HPV感染的发生率或危险因素知之甚少。尽管在印度,男性和女性中与HPV相关的癌症的背景发生率很高,但在印度,受HIV感染的MSM中肛门HPV感染的知识还很有限。印度感染HIV的MSM患肛门HPV感染和与HPV相关的疾病的风险特别高。我的目的是确定两个感染HIV的MSM人群中肛门HPV感染的发生率,发生率和危险因素,其中一个来自旧金山,第二个来自印度。旧金山的人口进行了为期两年的纵向研究,并进行了患病率和发病率分析。印度的研究是横断面设计,仅用于患病率分析。旧金山,在HIV感染的MSM中,肛门HPV感染的患病率为92%,致癌类型的患病率为80%,HPV 16的患病率为42%。终生伴侣的总数与HPV 16的患病率增加相关。任何肛门HPV感染的发生率是每100人年21.3(PY),HPV 16则是3.5 / 100。参与者是接受性伴侣与任何肛门HPV感染的发生率较高相关。新的接受伴侣,更频繁的接受性行为以及新的经口与肛门接触的伴侣也与任何肛门HPV感染的发生率较高相关。在感染了HIV的印度MSM中,肛门HPV感染的患病率为71%,并且曾经接受过肛门性交,并且较高的接受性伴侣数增加了患病率。 “几乎总是”使用安全套与接受性交的肛门,降低了感染了HIV的印度MSM中肛门HPV感染的发生率;结论:旧金山和印度的感染HIV的MSM在肛门HPV感染和肛门HPV的发生率均很高这些人在旧金山也很高。感染的最重要危险因素是男性伴侣总数和接受肛门的性交。避孕套可以预防肛门HPV感染,但是需要进一步的研究来证实结果。应与所有合作伙伴一起就感染艾滋病的MSM提供安全性行为方面的建议,并鼓励他们接受最近推荐的HPV疫苗。

著录项

  • 作者

    Hernandez, Alexandra Lydia.;

  • 作者单位

    University of California, Berkeley.;

  • 授予单位 University of California, Berkeley.;
  • 学科 Health Sciences Epidemiology.
  • 学位 Ph.D.
  • 年度 2011
  • 页码 100 p.
  • 总页数 100
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

  • 入库时间 2022-08-17 11:44:18

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