泛素连接酶CUL4A-DDB1复合体参与DNA损伤修复的研究进展

摘要

Ubiquitylation of protein plays an important role in DNA damage signaling transduction, including cell-cycle control, DNA repair, aging, as well as apoptosis. CUL4A-DDB1 E3 ligase recruits substrates through DCAFs for ubiquitylation and initiates the process of DNA excision repair for the removal of damaged DNA. Recent data suggest that the role of CUL4A-DDB1 E3 ligase is critical in genomic stability by regulating DNA damage, DNA repair, and DNA replication.%泛素化修饰在DNA损伤信号中发挥重要功能,包括细胞周期监控、DNA修复、细胞衰老和程序性死亡的调控.CUL4A-DDB1泛素连接酶通过DCAFs靶向调控特异性的底物,启动DNA切除修复机制对受损DNA进行修复.近期的研究表明CUL4A-DDB1泛素连接酶协助DNA修复因子与受损DNA的识别,来维持基因组的稳定性和正确性.