Objective To analyse the clinic and pathological features of gastroenteropancreatic neuroendocrine neo-plasma ( GEP-NEN) . Methods Medical records of 15 cases of GEP-NENs were collected in the Cancer Center of Guan-gzhou Medical University from 2000 to 2014,all the pathological specimens were reviewed according to WHO 2010 classfi-cation of tumors of the digestive system. The data were analyzed retrospectively,and the clinical and pathological characteris-tics were summarized. Results Among the 15 patients,the median age at diagnosis was 56 years. More common sites of occurrence were esophagus and pancreas,CgA positive rate was 73%,the Syn positive rate was 87%. Patients with stage IV disease or whose pathology classification were G3 had a poor prognosis. Conclusion GEP-NEN has the very high hetero-geneity,clinical staging and grading are the major prognostic factors. To achieve early diagnosis and treatment,clinical multi-disciplinary cooperation is needed. Early diagnosis and treatment can improve prognosis of patients.%目的 分析胃肠胰神经内分泌肿瘤的临床及病理特点. 方法 收集本院病理诊断为胃肠胰神经内分泌肿瘤的病例15例,按照2010年第4 版《WHO消化系统肿瘤分类》标准进行病理复核,回顾分析其临床资料,总结其临床及病理特点. 结果 15例胃肠胰神经内分泌肿瘤中,中位发病年龄为56岁. 发病部位多见于食管,其次为胰腺,CgA阳性率为73%,Syn阳性率为87%,分期为IV期及病理分级为3级的患者预后差. 结论胃肠胰神经内分泌肿瘤具有很高的异质性,临床分期及分级是主要的预后因素,早期诊断及治疗可改善患者预后.
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