98例胃肠胰神经内分泌肿瘤的临床病理特征及生存分析

摘要

Objective:To investigate the clinicopathological features and prognostic factors of 98 patients with gas-trointestinal pancreatic neuroendocrine tumors,so as to improve their understanding and diagnosis and treatment level. Methods:The data of 98 patients with gastrointestinal pancreatic neuroendocrine tumors were collected from January 2008 to June 2016 in Xinjiang Tumor Hospital.Their clinical manifestations,pathological features and survival were retrospectively analyzed.Results:There were 98 cases(67 males and 31 females)with a mean age of(54.5 ± 12.8) years. The incidence of the disease was most common in stomach(33/98,33.7%),followed by rectum(31/98, 31.6%).The tumor size ranged from 0.2 cm to 9.2 cm(mean size:1.2 cm).The mean follow-up time was 18 months(range 1~101 months).The 1,3 and 5-year overall survival rates were 80.6%、64.1%、56.2%,respec-tively.Univariate analysis showed that tumor location,size,grade,lymph node metastasis,distant metastasis and surgi-cal methods were poor prognostic factors.Multivariate analysis did not reveal any independent risk factors.Conclu-sion:Gastrointestinal pancreatic neuroendocrine tumor is a rare disease,the clinical manifestations are not typical,the most common place is the stomach,mostly high-grade malignancy,followed by the more common in the rectum,most-ly low-grade malignancies.Gastrointestinal pancreatic neuroendocrine tumors to surgical treatment based.%目的:探讨98例胃肠胰神经内分泌肿瘤的临床、病理特点及预后因素,以提高对该疾病的认识及诊治水平.方法:选取2008年1月至2016年6月新疆医科大学附属肿瘤医院收治98例资料完整的胃肠胰神经内分泌肿瘤患者的临床资料,对其临床表现、病理特征、生存等进行回顾性分析.结果:本组患者共98例(男67例,女31例),平均年龄(54.5 ± 12.8)岁,发病部位最常见于胃(33/98,33.7%),其次直肠(31/98、31.6%).肿瘤大小0.2至9.2厘米(平均:1.2厘米).平均随访时间为18个月(范围1~101个月).患者1年、3年和5年总生存率分别为80.6%、64.1%、56.2%.单因素分析显示肿瘤部位、大小、分级、淋巴结转移、远处转移及手术方式是预后不良的预测因子,多因素分析未发现任何独立的危险因素.结论:胃肠胰神经内分泌肿瘤是一种少见的疾病,临床表现不典型,最常见的发生部位是胃,多为高度恶性肿瘤;其次多见于直肠,多为低度恶性肿瘤.胃肠胰神经内分泌肿瘤以手术治疗为主.