Objective Compare look cervical biopsy with conventional multi-point difference in cervical biopsy in the diagnosis of cervical disease. Methods A retrospective analysis of our hospital has treated patients with concurrent cervical conization diagnosed with the disease, a total of 218 cases, depending on the preoperative biopsy or the use of multi-point look routine biopsy grouped into observation group and control group. The two groups were compared for diagnostic accuracy, sensitivity, specificity, positive predictive value, negative predictive value, invasive cervical cancer misdiagnosis rate and other indicators. Results The sensitivity of the observation group was 97.8%, specificity 96.8%, positive predictive value of 91.2%, negative predictive value of 96.5%, invasive cervical cancer misdiagnosis rate was 8.3%;sensitivity of the control group was 61.4%, specificity 85.4%, positive predictive value 54.3%, negative predictive value of 88.2% of invasive cervical cancer misdiagnosis rate of 75%. Conclusion Look cervix multiple biopsies with high sensitivity and diagnostic accuracy of cervical disease, especially for the type of CIN and invasive diagnosis. Their results are satisfactory, with a high clinical value.%目的：比较直视宫颈多点活检与常规宫颈活检在宫颈疾病诊断中的差异。方法采用回顾性分析法，对我院曾收治并行宫颈锥切术确诊的宫颈疾病患者，共计218例，按照术前采用直视多点活检或常规活检分组为观察组和对照组。分别比较两组诊断符合率，灵敏度、特异性、阳性预测值、阴性预测值、宫颈浸润癌漏诊率等指标。结果观察组灵敏度为97.8%，特异性为96.8%，阳性预测值91.2%，阴性预测值96.5%，宫颈浸润癌漏诊率为8.3%；而对照组灵敏度为61.4%，特异性85.4%，阳性预测值54.3%，阴性预测值88.2%，宫颈浸润癌漏诊率75%。结论直视宫颈多点活检在宫颈疾病中具有较高的灵敏度及诊断符合率，尤其是对于CIN类型及浸润癌的诊断，具有较高临床应用价值。
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