Objective To investigate the clinical effect of milrinone combined with high frequency ventilation in the treatment of neonatal pulmonary hypertension .Methods 40 neonatal patients with pulmonary hypertension in the neonatal intensive care unit (NICU ) of our hospital were selected and randomly divided into two groups ,20 cases in each group .The control group was given the high frequency ventilation ,symptomatic therapy and supportive treat‐ment ,on this basis the treatment group was added with milrinone ,loading dose of 50 μg/kg and maintenance dose of 0 .50 - 0 .75 μg/ (kg ・ min) by micropump continuous infusion .The clinical effective rate ,blood gas and blood pres‐sure after 3 d treatment were compared between before and after treatment .Results (1)The symptoms after treat‐ment in the two group were improved ,the effective rate in the treatment group was 85% ,which was significantly higher than 70% in the control group ,the difference was statistically significant (P< 0 .05) .(2)The blood gas levels after treatment in the two groups were improved ,and the improvement in the treatment group was more obvious than the control group ,the difference was statistically significant (P< 0 .05) .(3) the blood pressure after treatment in the two groups was improved ,but the improvement in the treatment group was more obvious ,the difference was statisti‐cally significant (P < 0 .05) .Conclusion Milrinone combined with high frequency ventilation can significantly im‐prove the clinical symptoms of neonatal pulmonary hypertension ,has the guidance significance in clinic and is worth clinical promotion .%目的：探讨米力农联合高频通气治疗新生儿肺动脉高压临床疗效。方法选取周至县人民医院和陕西省人民医院收治的新生儿肺动脉高压患儿40例，随机分为对照组和治疗组，每组20例。对照组给予高频通气及对症治疗和支持治疗，治疗组在常规治疗的基础上加用米力农，负荷量50μg／kg ，维持量0．50～0．75μg／（kg ・min）微量泵持续给入。治疗3 d 后，对比治疗前后患儿临床有效率、血气及血压。结果（1）治疗后两组患者症状均有改善，且治疗组有效率（85％）明显高于对照组（70％），差异有统计学意义（P＜0．05）；（2）两组患者血气水平均有改善，且治疗组较对照组明显好转，差异有统计学意义（P ＜0．05）；（3）治疗后两组患者血压改善，且治疗组血压较对照组明显好转，差异有统计学意义（P＜0．05）。结论米力农联合高频通气能够明显改善新生儿肺动脉高压的临床症状，对临床具有指导意义，值得临床推广。
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