SLC2A9基因R265H位点单核苷酸多态性与痛风易感性的Meta分析

摘要

目的：探索 SLC2A9基因 R265H 位点突变与痛风易感性间的关联。方法检索6个电子数据库，获得 SLC2A9基因 R265H 位点与痛风相关的文献，对纳入文献进行质量评价后，运用 RevMan 5．0和 Stata 11．0软件进行 Meta 分析。结果共纳入文献6篇，包含5182例参与者（痛风病人1999例，正常对照3183例）。经 Meta分析发现，SLC2A9基因 rs3733591位点 SNPs 与痛风易感性在 TT vs CC＋CT 和 CC vs TT＋CT 模型及 C 等位基因中存在统计学关联，在 CT vs TT＋CC 模型中无统计学差异（TT vs CC＋CT：OR ＝0．71，95％ CI ＝0．61～0．84，P ＜0．0001；CC vs TT＋CT：OR ＝1．23，95％ CI ＝1．06～1．42，P ＝0．006；C 等位基因：OR ＝2．39，95％ CI＝1．98～2．89，P ＜0．0001；CT vs TT＋CC：OR ＝1．06，95％ CI ＝0．94～1．20，P ＝0．36）。亚组分析发现，仅 TT vs CC＋CT 和 CC vs TT＋CT 模型在亚洲人群中有统计学差异，其余均无统计学差异（TT vs CC＋CT：OR ＝0．66，95％ CI ＝0．55～0．80，P ＜0．0001；CC vs TT＋CT：OR ＝1．45，95％ CI ＝1．19～1．77，P ＝0．003）。纳入研究结果间无异质性及发表偏倚。结论 SLC2A9基因 rs3733591位点多态性与痛风易感性在亚洲人群中可能存在关联，且 C 等位基因可能增加患痛风的风险。%Objective To analyze the association between the rs3733591 variant and gout risk.Methods We examined 6 electronic literature databases,performed quality assessment of the related articles,then used Review Manager 5.1 software and Stata 11.0 software to perform statistical analyses.Results Totally,6 studies were recruited in our study,which contained 5182 participants (1999 gout patients and 3183 con-trols).There were significant associations in TT vs CC+CT,CC vs TT+CT models and C allele,but not in CT vs TT+CC model (TT vs CC+CT:OR =0.71,95% CI =0.61 - 0.84,P <0.0001;CC vs TT+CT:OR =1.23,95% CI = 1.06 - 1.42,P =0.006;C allele:OR =2.39,95% CI = 1.98 - 2.89,P <0.000 1;CT vs TT+CC:OR =1.06,95% CI =0.94 - 1.20,P =0.36).Subgroup analysis showed that only TT vs CC+CT and CC vs TT+CT models had a significant associations in Asian populations (TT vs CC+CT:OR =0.66,95% CI =0.55 - 0.80,P <0.000 1;CC vs TT+CT:OR =1.45,95% CI =1.19 -1.77,P =0.003).There were no heterogeneity and publication bias in the results.Conclusion Maybe, there were association between rs3733591 SLC2A9 gene variant and gout risk in Asian populations,and the C allele may increase the gout risk.