Objective To explore the correlationship between level of bFGF (basic fibroblast growth factor) in serum and synovia and X-ray severity (Kellgren-Lawrence Grading System) in patients with knee OA. Method 68 patients with knee OA were enrolled into this study. Knee OA grading was evaluated according to the Kellgren-Lawrence classification. bFGF levels in both serum and synovia were examined using enzyme-linked immunosorbent assay. Results The level of bFGF in serum and synovial fluid in patients with knee OA were positively correlated with radiographic severity (r = 0.619, P < 0.001 and r = 0.603, P < 0.001, respectively). Further analysis revealed that there was a positive correlation between the level of bFGF in serum and in synovia fluid (r = 0.688, P < 0.001). Conclusions Levels of bFGF in serum and synovial fluid were significantly increased in patients with OA, and levels of bFGF were positively correlated with radiographic severity. These findings indicate that bFGF levels may be a biomarker of disease severity and could play an crucial part in the pathophysiology of degenerative process in OA.%目的：探讨骨关节炎（ OA ）患者关节滑液和血清中 bFGF （ basic fibroblast growth factor ，碱性成纤维细胞生长因子）与 OA X 线上 Kellgren-Lawrence （ K-L ）分级严重程度的相关性。方法：68例经南方医院和清远市人民医院诊断为 OA 的患者纳入本次研究，关节滑液和血清中 bFGF 含量采用 ELISA检测方法，膝骨关节炎影像学严重程度评分采用国际公认的 Kellgren-Lawrence 评分系统。结果：血清和关节滑液 bFGF 水平与骨关节炎影像学分级有显著相关性（r ＝0．619，P ＜0．001和 r ＝0．603，P ＜0．001），此外血清 bFGF 水平和滑液中 bFGF 水平呈正相关（ r ＝0．688， P ＜0．001）。结论：血清和关节滑液 bFGF 水平在 OA 患者中显著升高，且与影像学 Kellgren-Lawrence 分级严重程度呈正相关。这表明bFGF 可作为 OA 严重程度的标记物，在 OA 的进展中起到重要作用，为 OA 的临床实验诊断开辟了新的道路。
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