脂蛋白（a）与急性冠脉综合征患者冠脉左主干病变的相关性

摘要

Objectives To explore the correlation between lipoprotein (a) and left main coronary artery ( LMCA) disease in patients with acute coronary syndrome (ACS). Methods A total of 264 ACS patients managed with coronary angiography (CAG) from June 2012 to December 2013 were included in the study and then they were divided into 2 groups (high-Lp(a) (> or = 300 mg/L) group (n = 93) and low-Lp(a) (< 300 mg/L)group(n = 171). The clinical data were studied and compared between the two groups. Binary unconditional logistic regression analysis was used to select the risk factors of LMCA disease. Results The percentages of multiple branch lesion (43.0% vs. 25.1%) and LMCA disease (17.2% vs. 8.2%)were higher in the high-Lp(a) group as compared with the low-Lp(a) group (P<0.05). Logistic regression analysis showed Lp(a) was independent factor of LMCA disease. Conclusions In ACS patients the elevated Lp(a) levels are associated with the severity of coronary disease and Lp(a) is an independent factor of LMCA disease.%目的：探索急性冠脉综合征患者脂蛋白（a）[Lp（a）]与冠脉左主干病变的相关性。方法：收集2012年6月至2013年12月行冠脉造影的急性冠脉综合征患者264例。根据LP（a）水平将入选的病例分为两组，Lp（a）正常组（≤300 mg／L）（n ＝171）以及Lp（a）升高组（＞300 mg／L）（n ＝93）。对比两组间的基线资料、多支血管病变及左主干病变的发生率，进行二分类非条件Logistic回归分析筛查左主干病变发生的危险因素。结果：Lp（a）升高组与Lp（a）正常组相比，有更高的三支血管病变及左主干病变发生率，差异均有统计学意义（P ＜0．05）。 Logistic 回归结果显示： Lp（a）与左主干病变的发生呈独立正相关。结论：急性冠脉综合征患者的Lp（a）水平与冠脉病变的严重程度相关，高Lp（a）水平患者有更高的左主干病变发生率。