桂皮提取物对糖尿病大鼠血糖和血脂含量的影响

摘要

【Objective】 The study was conducted on the effects of cinnamon on blood sugar and lipid levels in diabetic rats.【Method】 The diabetic rats were induced by intraperitoneal injection of 200 mg/kg alloxan to establish diabetic model.The rats were divided into control group（Ⅰ）,model group（Ⅱ）,low dose cinnamon treating group（Ⅲ） and high dose cinnamon treating group（Ⅳ）.The diabetic rats of group Ⅲ and Ⅳ were orally administered with 100 and 200 mg/（kg·d） cinnamon extract respectively,for 30 days.The rats of group Ⅰ and Ⅱ were orally administered with saline respectively by the same way and the same dose.The daily feed consume,water intake and urine excretion were recorded.The blood sugar,TC,TG,LDL-C,HDL-C level and the body weight were estimated at 0 and 30 d.【Result】 Compared with the rats of group Ⅰ,the body weight of all the diabetic rats of group（Ⅱ,Ⅲ and Ⅳ） decreased significantly（P0.05）,and the blood sugar level increased significantly（P0.05） at 0 d.Compared with the rats of groupⅡ,the blood sugar,TC,TG,LDL-C level of the diabetic rats in group Ⅳdecreased significantly（P0.05）,the body weight and HDL-C level increased significantly（P0.05） at 30 d.Compared with the rats of group Ⅰ,there were no differences in body weight,blood sugar,TC,TG,LDL-C and HDL-C level of the diabetic rats in group Ⅳ at 30 d（P0.05）.【Conclusion】 The cinnamon extract（200 mg/（kg ·d）） decreased the blood sugar,TC,TG and LDL-C level of the diabetic rats induced by alloxan,increased the body weight and enhanced HDL-C level.Enrichment of cinnamon with cinnamate can provide a functional food spice that could potentially benefit human health.%【目的】探讨桂皮提取物对糖尿病大鼠血糖和血脂含量的影响。【方法】给大鼠腹腔注射200mg/kg的四氧嘧啶建立糖尿病模型。试验共分4组：正常对照组（Ⅰ）、糖尿病模型组（Ⅱ）、低剂量桂皮提取物组（Ⅲ）和高剂量桂皮提取物组（Ⅳ）,Ⅲ、Ⅳ组糖尿病模型大鼠分别灌服100和200mg/（kg.d）的桂皮提取物,连续灌服30d;Ⅰ、Ⅱ组大鼠分别灌服生理盐水,方法和剂量同前。试验期间观测各组大鼠饮食、尿量,并在0d（开始时）和30d时,取样测定大鼠血糖、血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL-C）、高密度脂蛋白（HDL-C）水平和体质量。【结果】试验开始时,与Ⅰ组相比,Ⅱ、Ⅲ和Ⅳ组大鼠体质量显著降低（P〈0.05）,血糖显著提高（P〈0.05）。试验结束时,与Ⅱ组相比,Ⅳ组大鼠血糖及血清TC、TG和LDL-C水平显著降低（P〈0.05）,而体质量和HDL-C水平显著升高（P〈0.05）;而Ⅳ组与Ⅰ组相比,大鼠体质量、血糖及血清TC、TG、LDL-C和HDL-C水平差异均不显著（P〉0.05）。【结论】灌服200mg/（kg.d）的桂皮提取物,能够降低四氧嘧啶所致糖尿病大鼠的血糖及血清TC、TG和LDL-C水平,增加其体质量,提高其血清HDL-C水平。