Effects of onion kimchi extract supplementation on blood glucose and serum lipid contents in streptozotocin-induced diabetic rats.

摘要

The effects of onion kimchi extract supplementation for 4 wk on blood glucose levels and serum lipid components in streptozotocin (STZ)-induced diabetic rats was studied. STZ was administered as a single dose (50 mg/kg body wt.) to induce diabetes and the diabetic rats were divided into 8 groups (normal, diabetic control and 6 treatment groups). Onion kimchi extract at a dose of 100 (OK-100), 200 (OK-200) or 400 (OK-400) mg/kg/day or quercetin as a main compound of onion at a dose of 5 (Q-5), 10 (Q-10) or 20 (Q-20) mg/kg/day were orally administered daily to STZ-induced diabetic rats for 4 wk after STZ injection. The diabetic control rats showed significantly higher blood glucose levels (465.6 mg/dl) than the normal rats (76.3 mg/dl) after 4 wk, but this was significantly reduced by onion kimchi extract and quercetin supplementation (P < 0.001). Changes in body wt., kidney wt. and urine vol. were not significantly different in diabetic control rats and in onion kimchi extract and quercetin treated rats. Serum total cholesterol levels were significantly decreased in onion kimchi extract and quercetin supplementation groups compared to the controls (P < 0.001). Blood urea N level and urinary protein excretion in diabetic rats were not significantly different among groups. These results suggest that onion kimchi extract supplementation in STZ-induced diabetic rats may be an important factor for the reduction of blood glucose and serum cholesterol levels.