Objective To investigate and compare the efficacies between intraoperative submucosal pirurubicin ( THP) injection and postoperative instillation of THP in preventing the recurrence of superficial bladder tumor after transurethral resection of bladder tumor(TURBT). Methods 56 patients were randomly divided into 2 groups. group A and B. 20 mg THP was injected submucously during operation to patients in group A. Patients in group B received immediate instillation of 20 mg TPH within 6 hours post-operation. Results The recurrence rates and side effects after treatment were evaluated. The recurrence rates of group A (mean follow-up of 20. 1 months) and grou P B (mean follow-up of 19. 8 months) were 14. 8％ and 21. 4％ respectively, which were significantly different, (P＜0.05). No systemic side effect had been observed in all patients.Conclusion Intraoperative submucosal THP injection and immediate postoperative instillation of THP can both effectively reduce the recurrence rate of bladder tumor, but the former is more effective. No significant difference was found in side effects between the two groups.%目的 对比吡柔比星(THP)在经尿道膀胱肿瘤电切术中黏膜下注射与术后即刻膀胱灌注预防表浅性膀胱癌复发的疗效.方法 56例患者随机分为A、B两组.A组27例术中给与20 mg THP膀胱黏膜下注射;B组29例于手术当天6 h内20 mgTHP膀胱灌注.观察各组肿瘤复发情况、毒副反应.结果 A组平均随访20.1月,4例复发,复发率14.8%;B组平均随访19.8月,7例复发,复发率24.1%,两组之间的差异有统计学意义(P＜0.05).所有患者未见明显的全身性药物反应.结论 术中黏膜下注射和术后早期膀胱灌注显著降低表浅性膀胱癌术后复发率,其中术中黏膜下注射优于术后早期灌注,两组之间灌注后副作用无明显差异.
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