Objective: To investigate the clinicopathologic characteristics, differential diagnosis and prognosis of primary anaplastic large cell lymphoma ( ALCL) in bone and nasal cavity. Methods : Two cases of ALCL samples were fixed in 40 g/L neutral formalin, embeded in paraffin and stained by HE and immunohistochemical methods. Then, their histopathological characteristics and immunohistochemical features were observed, and these two patients were followed - up. Results : Both of these lesions showed diffuse infiltration by a population of mononuclear tumor cells, which were large and pleomorphic. The circumscription of tumor cells were clear, and cytoplasm were abundant. The nucelus were round or oval, with predominant nucleoli and frequent mitoses. The immunohistochemical stain showed the tumor cells were poaitive for CD30 , EMA , ALK and Clusterin. Conclusion : Primary anaplastic large cell lymphoma in bone and nasal cavity are extremely rare. The definite diagnosis should be based on the histopathological and im munohistochemical features to exclude other tumors.%目的:探讨2例原发于骨和鼻腔的间变性大细胞淋巴瘤(anaplastic large cell lymphoma, ALCL)的临床病理学特点、鉴别诊断和预后.方法:2例ALCL均经4%中性福尔马林固定、石蜡包埋、常规HE和免疫组化染色后观察其组织病理学特点和免疫学表型特征,并进行随访.结果:光镜下,2例病变区肿瘤细胞均呈弥漫性生长,异型性明显,体积大,界限清楚、胞浆丰富,核圆形或卵圆形,核仁明显,核分裂像易见.免疫组化结果示肿瘤细胞表达CD30、EMA、ALK和Clusterin.结论:原发于骨和鼻腔的ALCL罕见,明确诊断须依赖组织病理学观察和免疫学表型.
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