小 RNA 对胞内菌生长、毒力及铁水平的调节作用

摘要

Small RNA (sRNA) is a class of non‐coding RNA of 50‐500 bases with a regulatory function on transcription ,translation and mRNA stability .Bacterial sRNAs have been implicated in gene expression , cellular proliferation , virulence and adaptation to environmental conditions . The role of sRNAs in intracellular infection (such as Salmonella , Listeria , Legionella pneumophia , etc .) , including the regulation on growth ,virulence and host iron levels is reviewed in this paper .%细菌小RNA（small RNA ，sRNA）是一类长度为50～500个碱基，具有调控转录、翻译和mRNA稳定性的非编码调节性RNA。随着越来越多的sRNA被鉴定，部分细菌的sRNA功能已逐步阐明，主要参与调控细菌的基因表达、增殖、毒力及对环境的应激反应等生物学过程。本文就胞内菌（如沙门菌、李斯特菌、嗜肺军团菌等）sRNA对其自身在宿主细胞内的生长、毒力和铁水平的调控作用进行综述。