目的：评价被动抬腿试验（PLR）预测感染性休克患者的容量反应性。方法：采用前瞻性、观察性队列研究设计方法，选择34例感染性休克患者，先后进行 PLR 和容量负荷试验（VE），分别在 PLR 前（基线）、PLR 期间和 VE 后用超声心动图（TTE）测量记录每搏量（SV）并记录血流动力学变化。根据对容量负荷试验的反应（以 VE 后 SV 增加≥15％定义为有容量反应性）将患者分为有反应组和无反应组。用受试者工作特征曲线（ROC 曲线）评价 PLR 预测感染性休克患者的容量反应性。结果：34例患者中有反应组16例，无反应组18例。 VE 和 PLR 引起的ΔSV 存在显著直线相关性，Person 相关系数为0．630，P＝0．000；PLR 诱导的ΔSV 预测感染性休克患者的容量反应性 ROC 曲线下面积（AUC）为0．866±0．064[95％可信区间（CI）为0．741～0．992，P＝0．000]，在 PLR 期间ΔSV 为11．84％时诊断容量反应性的敏感度为93．8％，特异度为72．2％。结论：PLR 在预测感染性休克患者的容量反应性具有良好的价值。%Objective :To investigate the ability of passive leg raising (PLR) trial predicting volume responsiveness in septic shock .Methods :The prospective and observational cohort study was performed in 34 septic shock patients .PLR and volume expansion(VE) has been carried out successively .Respectively ,in front of the PLR (baseline) ,during the period of PLR and after VE using echocardiography measure stroke volume (SV) and hemodynamic changes in the re‐cord .According to the responsiveness of volume expansion (Responders were defined by the appearance of an increase in SV ≥ 15% after VE) ,patients were divided into responders and non‐responders .Using the receiver operating char‐acteristic curve (ROC curve) analysis PLR assessment of volume responsiveness in patients with septic shock .Results :A total of 34 patients were evaluated and resulting in 16 responders and 18 non‐responders .There was a positive corre‐lation between ΔSV caused by VE and PLR ,Person correlation coefficient of 0 .630 ,P = 0 .000 ;area under the ROC curve (AUC) of PLR‐induced ΔSV predicting volume responsiveness in septic shock were 0 .866 ± 0 .064(95% CI 0.741~ 0 .992 ,P= 0 .000) .The ΔSV ≥ 11 .84% during PLR was found to predict volume responsiveness with a sensitivity of 93 .8% ,specificity of 72 .2% .Conclusion :Passive leg raising (PLR) has good predictive value in the evaluation of vol‐ume responsiveness in patients with septic shock .
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