Norepinephrine increases cardiac preload and reduces preload dependency assessed by passive leg raising in septic shock patients.

摘要

OBJECTIVE: : To assess the effects of norepinephrine on cardiac preload, cardiac index, and preload dependency during septic shock. DESIGN: : Prospective interventional study. SETTING: : Medical Intensive Care Unit. PATIENTS: : We included 25 septic shock patients (62 +/- 13 yrs old, Simplified Acute Physiology Score II 53 +/- 12, lactate 3.5 +/- 2.1 mmol/L, all receiving norepinephrine at baseline at 0.24 [25%-75% interquartile range: 0.12-0.48] mug/kg/min) with a positive passive leg raising test (defined by an increase in cardiac index >/=10%) and a diastolic arterial pressure