The opioid agonists employed primarily as moderate to strong analgesics have many pharmacological effects including vomiting,respiratory depression,constipation,and also have high possibility of addiction and dependence.Combinations of opioid agonists and opioid antagonists have been developed in recent years,and many clinical trials showed that such kind of drug combinations could moderate the side effects of opioid agonists and decrease the risk of drug abuse.Successful development of these combinations gives new options for the clinical application of opioid analgesics.%阿片受体激动剂是临床常用的镇痛药,通常用于中重度疼痛的治疗,但是此类药物常伴有明显的不良反应,如恶心、呕吐、便秘和呼吸抑制等,同时存在较高的成瘾性和依赖性,大大影响了药物的临床应用.近年来,阿片受体拮抗剂与阿片受体激动剂组成的复方药物陆续上市,临床试验显示此类复方制剂可以减轻不良反应,降低药物滥用的风险,为阿片类镇痛的临床应用提供了新的思路和选择.
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