一种新型气相色谱手性固定相的制备及应用

摘要

A new chiral stationary phase, 2,6 -di -O -trimethylsilyl -3 -O -acetyl -β -cyclodextrin, was synthesized, and coated on a fused silica capillary column with methyl -phenylsilicone oil as a diluent. Chromatographic properties of the stationary phase were investigated, and satisfactory resolutions were achieved for most of the studied enantiomers. The experimental results show that the acetylated and silylated β -cyclodextrin derivative is suitable for use as chiral stationary phase with good chromatographic properties such as high column efficiency, good thermal stability and inertness in separating enantiomers.%合成了一种新的手性固定相， 2,6 - 二 - O - 三甲基硅烷基 - 3 -O - 乙酰基 - β - 环糊精，以甲基苯基硅油为稀释剂，成功地将其涂渍到弹性石英毛细管柱上，该手性柱具有柱效高、惰性好、热稳定性好等色谱性能，对几类对映体进行了拆分，多数获得令人满意的效果。