高同型半胱氨酸血症与脑卒中高危人群颈动脉斑块性质的关系

摘要

[ABSTRACT]Objective:To analyze the relationship between hyperhomocysteinemia and carotid plaque features in high-risk stroke population.Methods:A total of 1 1 6 cases of high-risk stroke population treated in our hospital were included in study and divided into stable plaque group (n =32 cases),unstable plaque group (n =45 cases)and mixed plaque group (n =39 cases)according to plaque features after carotid artery ultrasonography.Differences in serum levels of homocysteine (Hcy), adhesion molecule,hypersensitive C-reactive protein,lipid,cell fibronectin,and so on were compared among groups,and the correlation between serum Hcy and plaque feature-related indicators was further analyzed.Results:Serum Hcy,sVCAM-1,sI-CAM-1,hs-CRP,TC,TG,LDL-C and c-Fn values of unstable plaque group were higher than those of stable plaque group and mixed plaque group,and HDL-C value was lower than that of stable plaque group and mixed plaque group (P <0.05);serum Hcy levels in high-risk stroke population were positively correlated with sVCAM-1,sICAM-1,hs-CRP,TC,TG,LDL-C and c-Fn values,and negatively correlated with HDL-C value.Conclusion:Hyperhomocysteinemia can promote the instability of ca-rotid plaque features in high-risk stroke population,and is a high-risk factor of stroke.%目的：：分析高同型半胱氨酸血症与脑卒中高危人群颈动脉斑块性质的关系.方法：选取于本院就诊的脑卒中高危人群116例纳入研究,经颈部血管超声检查后根据斑块性质分为稳定性斑块组32例、不稳定性斑块组45例、混合斑块组39例.对比各组血清同型半胱氨酸(Hcy)、黏附分子及高敏 C反应蛋白、血脂及细胞纤维结合蛋白等水平差异,并进一步分析血清 Hcy 与斑块性质相关指标间的相关关系.结果：不稳定性斑块组血清 Hcy、sVCAM-1、sICAM-1、hs-CRP、TC、TG、LDL-C、c-Fn 值高于稳定性斑块及混合型斑块组,HDL-C 值低于稳定性斑块及混合型斑块组(P ＜0．05)；脑卒中高危人群血清 Hcy 水平与 Hcy、sVCAM-1、sICAM-1、hs-CRP、TC、TG、LDL-C、c-Fn 值呈正相关关系,与 HDL-C 值呈负相关关系.结论：高同型半胱氨酸血症可以促进脑卒中高危人群颈动脉斑块性质不稳,是脑卒中发生的高危因素.