Role of aerobic exercise in hyperhomocysteinemia and hyperhomocysteinemia-accelerated atherosclerosis

摘要

@@ Introduction: Atherosclerosis is the leading cause of cardiovascular morbidity and mortality in the world. Over the decade, hyperhomocysteinemia (HHcy) has been recognized as an independent risk factor of atherosclerosis. Recently, the critical roles of inflammation and reactive oxygen species (ROS) in hyperhomocys-teinemia-accelerated atherosclerosis have been confirmed. However, there wasn t an effective intervention to be found to reduce the development of atherosclerosis induced by hyperhomocysteinemia. Aerobic exercise, as a key component of atherosclerosis prevention on the traditional risk factors, but which effect on plasma homo-cysteine (Hcy) level is contradictory now. Furthermore, it is unknown whether aerobic exercise could reduce hyperhomocysteinemia-accelerated atherosclerosis. Therefore, the purpose of the study was to investigate whether aerobic exercise could decrease Hcy level and reduce development of atherosclerosis induced by HHcy.