304株念珠菌感染分布及耐药性分析

摘要

Our objective is to investigate the drug resistance of Candida infection and give a clinical guidance to the rational use of drugs. The fungus was separate by conventional culture,the Candida spp was I-dentified by coloration medium and VITEK 32 automatic microorganism analysor,and the sensitivity was detected by drug analysing box. The results showed that the percent of Candida albicans, Candida tropicalis, Candida krusei,candida glabrata was 73. 7%, 14. 1%,4. 9% and 4. 3%,respectively,among 304 strains of Candida. The sensitivity of Candida albicans, Candida tropicalis and Candida glabrata treated with ketocon-azole was 90. 5% ,57.1% and 50.0%. A lower sensitivity of Candida albicans was found when treated with itraconazole. The sensitivity of Candida albicans treated with either miconazole or fluconazol was 82. 4% and 86. 5 %, respectively. There was a higher resistance of Candida tropicalis and Candida glabrata when treated with miconazole or fluconazol. Our conclusion is that Candida albicans infection is the main clinical Candida spp. Fluconazol is the first choice to administrate Candida spp infection. It is necessary to enforce clinically fungus' segregation,identification and sensitivity dectection,thus decreasing the drug-resistant strains.%为调查念珠菌的耐药情况,指导临床合理用药,采用常规培养分离真菌,用显色培养基和VITEK 32全自动微生物分析仪鉴定真菌,真菌药敏测定试剂盒分析药敏.结果显示,304株念珠菌中白色念珠菌、热带念珠菌、克柔氏念珠菌、光滑念珠菌分别为73.7％、14.1％、4.9％、4.3％.酮康唑对白色念珠菌、热带念珠菌、光滑念珠菌的敏感率分别为90.5％、57.1％、50.0％％,伊曲康唑对念珠菌的敏感性较差.咪康唑、氟康唑对白色念珠菌的敏感率分别为82.4％、86.5％,对热带念珠菌和光滑念珠菌的耐药性较高.表明临床念珠菌感染以白色念珠菌为主,氟康唑是临床较好的首选用药.临床必需加强对真菌的分离鉴定、药敏试验,减少耐药菌株的产生.