Influence of T-2 Mycotoxin on Host Resistance to Candida albicans Infections in Mice

摘要

Mice infected with Candida albicans and then exposed to two or three doses of T-2 mycotoxin by the gastric route died earlier and in greater numbers than controls. The ability of livers, lungs, and spleens to clear and kill the organisms was compromised by exposing mice to multiple doses of toxin. A single dose of toxin given before or after Candida challenge did not increase the mortality. These studies add further information regarding biological effects of this mycotoxin, and shows that increased hazards are involved when this compound amplifies the pathogenesis of microorganisms such as C. albicans.