CD58分子与急性淋巴细胞白血病和淋巴瘤相关性的研究进展

摘要

Lymphocyte function-associated antigen-3 (LFA-3/CD58) is a cell-surface glycoprotein,it can bind to CD2 and activate the costimulation pathways of T lymphocytes and natural killer (NK) cells,maximizing the cytolysis of target cells by cytotoxic T lymphocytes (CTL) and NK cells.Some studies have demonstrated that in acute lymphoblastic leukemia(ALL) and lymphomas,lack of CD58 on the tumor cells may fail to activate the T lymphocytes and NK cells,resulting in feeble cytotoxic effect and subsequently escape from immune surveillance,making the disease become more complicated and liable to relapse.Therefore,this article aims to review the structure,biological characteristics of CD58 on the tumor cells and its relationship with ALL and lymphomas.%淋巴细胞功能相关抗原-3(LFA-3/CD58)是细胞表面的一种糖蛋白,它与T淋巴细胞及自然杀伤(NK)细胞表面的CD2分子结合后可激活淋巴细胞的共刺激信号通路,从而使细胞毒性T淋巴细胞(CTL)或NK细胞最大限度地发挥对靶细胞的杀伤作用.有研究证实,在急性淋巴细胞白血病(ALL)和淋巴瘤中肿瘤细胞表面CD58分子表达减少或者缺失,有可能导致T淋巴细胞或自然杀伤(NK)细胞活化失败,无法有效地发挥杀伤作用,使肿瘤细胞逃避淋巴细胞的免疫监视,从而导致病情变得更加复杂,易于复发.本文旨在论述肿瘤细胞表面CD58分子的结构、生物学特点及其与急性淋巴细胞白血病和淋巴瘤的关系.