目的 探讨血管内皮生长因子C(VEGF-C)和血管内皮生长因子受体3(VEGFR-3)在直肠癌中的表达及其与临床病理学特征之间的关系.方法 运用免疫组织化学(SP法)检测55例直肠癌组织及相应切缘组织中VEGF-C、VEGFR-3蛋白的表达.结果 VEGF-C和VEGFR-3蛋白在直肠癌组织中,表达率分别为63.6%和60.0%,在切缘组织表达率较低,差异有统计学意义(P＜0.05 ),且VEGF-C和VEGFR-3在直肠癌中的表达呈正相关关系(r=0.386,P＜0.05),有无淋巴转移及不同Dukes分期的癌组织中VEGF-C和VEGFR-3表达率差异有统计学意义(P＜0.05 ).结论 VEGF-C和VEGFR-3在直肠癌组织中均呈高表达,并且两者的表达与直肠癌淋巴结转移情况密切相关.%Objective To investigate the expressions of vascular endothelial growth factor C( VEGF - C ) and vascular endothelial growth factor receptor 3 ( VEGFR - 3 ) in rectal cancer, and their relationship with the characteristics of clinical pathology. Methods Expressions of VEGF - C and VEGFR - 3 were detected in 55 tissue samples of rectal cancer and 55 tissue samples of corresponding normal tissue with immunohistochemistry. Results Significant differences were found in the positive rates of VEGF - C and VEGFR - 3 expressions between normal large intestine tissues and tissues of rectal cancer ( P ＜ 0.05 ). The expression of VEGF - C was positively correlated with the expression of VEGFR - 3in rectal cancer ( r=0. 386, P ＜ 0.05 ). The expressions of VEGF - C and VEGFR - 3 were higher in rectal cancer of Dukes stages A and B than in Dukes stages C and D, and higher in rectal cancer without lymph node metastasis than in rectal cancer with lymph node metastasis ( P ＜0.05 ). Conclusion The expressions of VEGF - C and VEGFR - 3 were high in rectal cancer, and both of them have significant realation with lymphnode metastasis.
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