VEGFR-3 mTOR A Method for Preventing or Treating mTOR-related Disorders via Regulation of VEGFR-3 Expression

摘要

The present invention relates to a composition for preventing or treating mTOR signaling deficiency-related diseases and mTOR (mammalian target of rapamycin)-mediated diseases, and a screening method thereof. The present invention provides an effective therapeutic target for various diseases caused by excessive activity or lack of activity of mTOR based on the new discovery that regulation of VEGFR-3 expression leads to regulation of mTOR signaling pathway activity. In particular, the present invention can be usefully used as a fundamental therapeutic agent for overlapping epilepsy, an intractable disease, by blocking the hyperexcited state in epilepsy and protecting nerves through VEGFR-3 activation.