METHOD FOR PREVENTING OR TREATING MTOR-ASSOCIATED DISEASES THROUGH REGULATION OF VEGFR-3 EXPRESSION

摘要

The present invention relates to a composition for preventing or treating mammalian target of rapamycin (mTOR)-mediated diseases and deficient mTOR signaling-associated diseases. The present invention provides an efficient therapeutic target for various disease caused by hyperactivity or deficient activity of mTOR, on the basis of the novel discovery that the regulation of VEGFR-3 expression leads to the regulation of mTOR signaling pathway activity. The present invention, especially through VEGFR-3 activation, blocks hyperexcitable states of epilepsy and protects nerves, and thus can be effectively used as a fundamental therapeutic agent for status epilepticus, which is an incurable disease.