methods to prevent or treat hyperlipidemia and one or more symptoms of a cardiovascular disease or condition caused by hyperlipidemia in a mammalian individual, to control hyperlipidemia in a mammalian individual, to treat one or more symptoms of cardiovascular disease, to modulate the expression of ldlr in a mammalian individual and to modulate the expression of ldlr in a mammalian individual and the activation of erk in a mammalian individual and to reduce cholesterol in a mammalian individual, compositions to prevent or alleviate hyperlipidemia, to treat or prevent hyperlipidemia in a mammalian individual to increase expression of ldlr in a mammalian individual, and in a mammalian cell, tissue, organ, or individual, to increase the stability of ldlr in a mammalian cell, tissue, organ or individual and to increase the stability of ldlr in a cell, tissue, mammalian organ or individual

摘要

METHODS FOR PREVENTING OR TREATING HYPERLIPIDEMIA AND ONE OR MORE SYMPTOMS OF A CARDIOVASCULAR DISEASE OR CONDITION CAUSED BY HYPERLIPIDEMIA, IN CONTROLING HYPERLIPIDEMIA IN A MODULAR CARDIOVASCULAR DISEASE A MAMMALIAN INDIVIDUAL AND TO MODULATE LDLR EXPRESSION IN A MAMMALIAN INDIVIDUAL AND ERK ACTIVATION IN A MAMMALIAN INDIVIDUAL AND TO REDUCE A MAMMALIAN INDIVIDUAL TO MAKE A PREVENTIVE OR HYPERIUM ALIPIDIUM LDLR EXPRESSION IN A MAMMALIUM INDIVIDUAL, AND IN A MAMMALIAN, TISSUE, ORGAN, OR INDIVIDUAL CELL, INCREASING LDLR STABILITY IN A MAMMALIAN, MALIUM AND AULAULAL CELL, A DIFFERENT CELL MAMMARY ORGAN OR INDIVIDUAL Methods and compositions containing a berberine compound or Berberine-derived or related compounds are provided for the treatment and prevention of hyperlipidemia, high cholesterol, and / or cardiovascular disease in mammalian subjects. The methods and compositions of the invention are effective for the prevention and treatment of atherosclerosis, coronary artery disease, angina pectoris, carotid artery disease, stroke, cerebral arteriosclerosis, elevated blood pressure, myocardial infarction, cerebral infarction, restenosis after angioplasty. balloon, intermittent claudication, postprandial lipidemia, dyslipidemia or xanthoma. Additional compositions and methods are provided that employ a berberine compound or berberine derivative or related compound in combination with a second antihyperlipidemia agent, or a different therapeutic agent to provide more effective treatment tools against hyperlipidemia and / or cardiovascular disease, and / or dual activity therapeutic methods and formulations usable for preventing or reducing hyperlipidemia and one or more related causal symptoms or conditions associated with hyperlipidemia in mammalian subjects.